Ap18 5

Ap18 5

SCHEMBL29357634

CC(=N/O)/C(C)=C/c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TRPA1 O75762 10/20 1.00
▸ CYP2C9 P11712 1/20 0.43
▸ SIGMAR1 Q99720 2/20 0.42
▸ ABCB11 O95342 1/20 0.42
▸ HDAC3 O15379 1/20 0.42
▸ HDAC4 P56524 1/20 0.42
▸ HDAC1 Q13547 1/20 0.42
▸ HDAC7 Q8WUI4 1/20 0.42
▸ HDAC2 Q92769 1/20 0.42
▸ HDAC10 Q969S8 1/20 0.42
▸ HDAC11 Q96DB2 1/20 0.42
▸ HDAC8 Q9BY41 1/20 0.42
▸ HDAC6 Q9UBN7 1/20 0.42
▸ HDAC9 Q9UKV0 1/20 0.42
▸ HDAC5 Q9UQL6 1/20 0.42
▸ PTGS2 P35354 1/20 0.41
▸ FBP1 P09467 1/20 0.39
▸ MAOB P27338 1/20 0.38
▸ GABRA1 P14867 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ap18 5 SCHEMBL1499479 1.00 TRPA1 (1.00) TRPA1CYP2C9SIGMAR1ABCB11HDAC3
Ap18 5 SCHEMBL1962033 1.00 TRPA1 (1.00) TRPA1CYP2C9SIGMAR1ABCB11HDAC3
Ap18 5 SCHEMBL12552586 1.00 TRPA1 (1.00) TRPA1CYP2C9SIGMAR1ABCB11HDAC3
Ap18 5 SCHEMBL1499542 1.00 TRPA1 (1.00) TRPA1CYP2C9SIGMAR1ABCB11HDAC3
SCHEMBL11767293 0.81 TRPA1 (0.68) TRPA1CYP2C9SIGMAR1ABCB11HDAC3
SCHEMBL28252409 0.79 TRPA1 (0.66) TRPA1CYP2C9SIGMAR1ABCB11FBP1
SCHEMBL3668616 0.76 TRPA1 (0.61) TRPA1SIGMAR1ABCB11
SCHEMBL3668618 0.76 TRPA1 (0.61) TRPA1SIGMAR1ABCB11
SCHEMBL22995639 0.75 TRPA1 (0.60) TRPA1CYP2C9HDAC3HDAC4HDAC1
SCHEMBL22995643 0.75 TRPA1 (0.60) TRPA1CYP2C9HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119483579-A Signal transmission system and method in isolation driving circuit 苏州炬仁半导体有限公司 2025-02-18 — — CN claimed
CN-222283315-U Signal conversion circuit capable of outputting multi-channel video signals for splicing display 深圳市华创科智技术科技有限公司 2024-12-31 — — CN claimed
EP-4434802-A1 FUEL CELL SYSTEMS WITH ENDURANCE BRAKING SUPPORT VOLVO TRUCK CORPORATION (SE) 2024-09-25 — — EP claimed
CN-118684620-A Betel nut alkaloid and preparation method and application thereof 暨南大学 2024-09-24 — — CN claimed
US-20240251664-A1 LIGHT EMITTING ELEMENT AND AMINE COMPOUND FOR THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2024-07-25 — — US claimed
CN-117119132-A GPU video input interface VIP 中国船舶集团有限公司第七一六研究所 2023-11-24 — — CN claimed
US-20230372350-A1 ASTROCYTIC TRPA1 CHANNEL INHIBITION AS A NOVEL NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE UNIVERSITE GRENOBLE ALPES (FR) 2023-11-23 — — US claimed
EP-4213823-A1 ASTROCYTIC TRPA1 CHANNEL INHIBITION AS A NOVEL NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE Université Grenoble Alpes (FR) 2023-07-26 — — EP claimed
CN-116437920-A Astrocyte TRPA1 channel inhibition as a novel neuroprotective therapeutic target for the precursor phase of Alzheimer's disease 格勒诺布尔大学 2023-07-14 — — CN claimed
CN-115967620-A Method and device for automatically realizing directional matching of ground station network equipment 中国卫通集团股份有限公司 2023-04-14 — — CN claimed
WO-2022058946-A1 ASTROCYTIC TRPA1 CHANNEL INHIBITION AS A NOVEL NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE UNIVERSITÉ GRENOBLE ALPES (FR) 2022-03-24 — — WO claimed
EP-4748447-A2 INFLUENZA VIRUS VACCINES AND USES THEREOF Icahn School of Medicine at Mount Sinai (US) 2026-05-27 — — EP disclosed
US-20260143965-A1 LIGHT EMITTING ELEMENT, AMINE COMPOUND FOR THE LIGHT EMITTING ELEMENT, AND DISPLAY DEVICE INCLUDING THE LIGHT EMITTING ELEMENT SAMSUNG DISPLAY CO LTD (KR) 2026-05-21 — — US disclosed
WO-2026107083-A2 SHELF-STABLE LOXSH CATALYST SOLUTION COMPOSITIONS COMPRISING SOLUBLE HIGH HYDRIDE CONCENTRATIONS AND THE PROCESSES FOR PREPARING THEM ALBEMARLE CORPORATION (US) 2026-05-21 — — WO disclosed
US-20260062460-A1 METHODS FOR TREATING ACUTE CORONARY SYNDROME USING APOA-1 FUSION PROTEINS THERIPION, INC. (US) 2026-03-05 — — US disclosed
EP-3954672-A1 VERMICOMPOST PRODUCTION METHOD Excelsior Inc. (JP) 2022-02-16 — — EP disclosed
US-11241442-B2 Methods of use for TRP channel antagonist-based combination cancer therapies PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-02-08 — — US disclosed
US-20220026803-A1 RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2022-01-27 — — US disclosed
US-20220026805-A1 RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2022-01-27 — — US disclosed
US-20220026804-A1 RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2022-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260062460-A1 METHODS FOR TREATING ACUTE CORONARY SYNDROME USING APOA-1 FUSION PROTEINS PON1, APOB, APOL1 TRPA1 4707/4885CYP2C9 1610/4885SIGMAR1 3120/4885
US-20230372350-A1 ASTROCYTIC TRPA1 CHANNEL INHIBITION AS A NOVEL NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE TRPA1, APP, TRPV2 TRPA1 1/4885CYP2C9 3399/4885SIGMAR1 1141/4885
US-20260143965-A1 LIGHT EMITTING ELEMENT, AMINE COMPOUND FOR THE LIGHT EMITTING ELEMENT, AND DISPLAY DEVICE INCLUDING THE LIGHT EMITTING ELEMENT NR2E3, NR2E1, NR0B2 TRPA1 377/4885CYP2C9 1201/4885SIGMAR1 475/4885
US-20240251664-A1 LIGHT EMITTING ELEMENT AND AMINE COMPOUND FOR THE SAME NES, NFE2L2, NUCB2 TRPA1 481/4885CYP2C9 863/4885SIGMAR1 1295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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