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Sugi Predict / Compounds / SCHEMBL1499744

SCHEMBL1499744

SCHEMBL1499744

NOP(=O)(O)C(c1ccc(O)cc1)P(=O)(O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 1/20 0.44
▸ CA12 O43570 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ MMP2 P08253 1/20 0.39
▸ IDO1 P14902 2/20 0.38
▸ TDO2 P48775 1/20 0.38
▸ PGK1 P00558 2/20 0.36
▸ PGK2 P07205 2/20 0.36
▸ GRM8 O00222 1/20 0.36
▸ GRM4 Q14833 1/20 0.36
▸ ESR1 P03372 4/20 0.34
▸ ESR2 Q92731 4/20 0.34
▸ PDCD1 Q15116 1/20 0.34
▸ CD274 Q9NZQ7 1/20 0.34
▸ TAAR1 Q96RJ0 2/20 0.34
▸ HTR3A P46098 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ NFKB1 P19838 1/20 0.34
▸ HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3385301 0.83 SRC (0.67) SRC
SCHEMBL5936840 0.82 SRC (0.62) SRCCA12CA1CA2MMP2
SCHEMBL9301497 0.72 SRC (0.75) SRCCA12CA1CA2MMP2
SCHEMBL10454829 0.69 ACP3 (0.59) CA12CA1CA2MMP2PGK1
Hydrochloric Acid SCHEMBL5935336 0.68 CA12 (0.44) SRCCA12CA1CA2MMP2
SCHEMBL5665228 0.68 GAA (0.47) CA12CA1CA2ESR1ESR2
SCHEMBL10252598 0.67 PGK1 (0.61) CA12CA1CA2MMP2PGK1
SCHEMBL744205 0.67 SRC (0.60) SRCPGK1PGK2GRM8GRM4
SCHEMBL2171583 0.66 SRC (0.65) SRCPGK1PGK2
SCHEMBL14965495 0.66 CA12 (0.45) SRCCA12CA1CA2MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2234620-B1 TRITHERAPY USED TO TREAT A PATIENT INFECTED BY HIV UNIV AIX MARSEILLE (FR) 2016-03-09 — — EP claimed
EP-2252282-B1 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AN HMG-CoA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATE SYNTHASE INHIBITOR UNIV AIX MARSEILLE (FR) 2015-07-15 — — EP claimed
JP-2011508764-A — — 2011-03-17 — — JP claimed
EP-2252282-A2 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION Université de la Méditerranée - Aix-Marseille II (FR) 2010-11-24 — — EP claimed
EP-2234620-A2 COMPOSITION AND METHODS USED DURING ANTI-HIV TREATMENT Université de la Méditerranée - Aix-Marseille II (FR) 2010-10-06 — — EP claimed
WO-2009115652-A2 COMPOSITION AND METHODS USED DURING ANTI-HIV TREATMENT UNIVERSITE DE LA MEDITERANNEE, AIX-MARSEILLE II (FR) 2009-09-24 — — WO claimed
WO-2009112653-A2 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION UNIVERSITE DE LA MEDITERRANEE, AIX-MARSEILLE II (FR) 2009-09-17 — — WO claimed
EP-2034985-A1 COMBINATION OF AN HMG-COA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATASE SYNTHASE INHIBITOR FOR THE TREATMENT OF DISEASES RELATED TO THE PERSISTENCE AND/OR ACCUMULATION OF PRENYLATED PROTEINS Université de la Méditerranée - Aix-Marseille II (FR) 2009-03-18 — — EP claimed
WO-2008003864-A1 COMBINATION OF AN HMG-COA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATASE SYNTHASE INHIBITOR FOR THE TREATMENT OF DISEASES RELATED TO THE PERSISTENCE AND/OR ACCUMULATION OF PRENYLATED PROTEINS UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II (FR) 2008-01-10 — — WO claimed
EP-2921172-B1 Combination of an HMG-CoA reductase inhibitor and a farnesyl-pyrophosphatase synthase inhibitor for the treatment of diseases related to the persistence and/or accumulation of prenylated proteins UNIV AIX MARSEILLE (FR) 2018-09-12 — — EP disclosed
EP-2234620-B1 TRITHERAPY USED TO TREAT A PATIENT INFECTED BY HIV UNIV AIX MARSEILLE (FR) 2016-03-09 — — EP disclosed
EP-2921172-A1 Combination of an HMG-CoA reductase inhibitor and a farnesyl-pyrophosphatase synthase inhibitor for the treatment of diseases related to the persistence and/or accumulation of prenylated proteins Universite d'Aix Marseille (FR) 2015-09-23 — — EP disclosed
EP-2252282-B1 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AN HMG-CoA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATE SYNTHASE INHIBITOR UNIV AIX MARSEILLE (FR) 2015-07-15 — — EP disclosed
EP-2034985-B1 COMBINATION OF AN HMG-COA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATASE SYNTHASE INHIBITOR FOR THE TREATMENT OF DISEASES RELATED TO THE PERSISTENCE AND/OR ACCUMULATION OF PRENYLATED PROTEINS UNIV AIX MARSEILLE (FR) 2015-05-06 — — EP disclosed
EP-2252282-A2 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION Université de la Méditerranée - Aix-Marseille II (FR) 2010-11-24 — — EP disclosed
EP-2234620-A2 COMPOSITION AND METHODS USED DURING ANTI-HIV TREATMENT Université de la Méditerranée - Aix-Marseille II (FR) 2010-10-06 — — EP disclosed
WO-2009115652-A2 COMPOSITION AND METHODS USED DURING ANTI-HIV TREATMENT UNIVERSITE DE LA MEDITERANNEE, AIX-MARSEILLE II (FR) 2009-09-24 — — WO disclosed
WO-2009112653-A2 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION UNIVERSITE DE LA MEDITERRANEE, AIX-MARSEILLE II (FR) 2009-09-17 — — WO disclosed
EP-2034985-A1 COMBINATION OF AN HMG-COA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATASE SYNTHASE INHIBITOR FOR THE TREATMENT OF DISEASES RELATED TO THE PERSISTENCE AND/OR ACCUMULATION OF PRENYLATED PROTEINS Université de la Méditerranée - Aix-Marseille II (FR) 2009-03-18 — — EP disclosed
WO-2008003864-A1 COMBINATION OF AN HMG-COA REDUCTASE INHIBITOR AND A FARNESYL-PYROPHOSPHATASE SYNTHASE INHIBITOR FOR THE TREATMENT OF DISEASES RELATED TO THE PERSISTENCE AND/OR ACCUMULATION OF PRENYLATED PROTEINS UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II (FR) 2008-01-10 — — WO disclosed