Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20389658 | 0.75 | CYP2C19 (0.37) | JAK1 | |
| SCHEMBL15016940 | 0.74 | ADORA3 (0.33) | — | |
| SCHEMBL30682140 | 0.71 | HPGD (0.35) | — | |
| SCHEMBL28412458 | 0.71 | HPGD (0.35) | — | |
| SCHEMBL16476633 | 0.70 | KDM4E (0.33) | — | |
| SCHEMBL14769541 | 0.69 | AHR (0.35) | — | |
| SCHEMBL16341884 | 0.67 | KDM4E (0.46) | — | |
| SCHEMBL15016943 | 0.67 | PLK4 (0.38) | — | |
| SCHEMBL31313054 | 0.66 | JAK1 (0.33) | JAK1 | |
| SCHEMBL30367579 | 0.65 | PDPK1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106317056-B | Pyrazolopyrimidine derivatives, process for their preparation and their therapeutic use | 赛诺菲 | 2020-06-23 | — | — | CN | disclosed |
| EP-2791137-B1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2019-01-23 | — | — | EP | disclosed |
| US-10138235-B2 | Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof | SANOFI (FR) | 2018-11-27 | — | — | US | disclosed |
| EP-3007694-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER | SANOFI SA (FR) | 2018-07-18 | — | — | EP | disclosed |
| US-20170231998-A1 | Pyrazolopyridine Derivatives, Preparation Process Therefor And Therapeutic Use Thereof | SANOFI (FR) | 2017-08-17 | — | — | US | disclosed |
| US-20170174681-A1 | Pyrazolopyridine Derivatives, Preparation Process Therefor And Therapeutic Use Thereof | SANOFI (FR) | 2017-06-22 | — | — | US | disclosed |
| US-9572799-B2 | Pyrazolopyridine derivatives for use in the treatment of bladder cancer | SANOFI (FR) | 2017-02-21 | — | — | US | disclosed |
| US-20160128989-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER | SANOFI (FR) | 2016-05-12 | — | — | US | disclosed |
| EP-3007694-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER | SANOFI (FR) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198942-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER | SANOFI (FR) | 2014-12-18 | — | — | WO | disclosed |
| US-20140350006-A1 | Pyrazolopyridine Derivatives, Preparation Process Therefor And Therapeutic Use Thereof | SANOFI (FR) | 2014-11-27 | — | — | US | disclosed |
| EP-2791137-A1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013087744-A1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160128989-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER | DPYD, QDPR, UROD | JAK1 1720/4885 |
| US-20170174681-A1 | Pyrazolopyridine Derivatives, Preparation Process Therefor And Therapeutic Use Thereof | FGF1, FGF2, FGFR1 | JAK1 245/4885 |
| US-10138235-B2 | Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof | FGF1, FGF2, FGFR1 | JAK1 245/4885 |
| US-20170231998-A1 | Pyrazolopyridine Derivatives, Preparation Process Therefor And Therapeutic Use Thereof | FGF1, FGF2, FGFR1 | JAK1 245/4885 |
| US-20140350006-A1 | Pyrazolopyridine Derivatives, Preparation Process Therefor And Therapeutic Use Thereof | FGF1, FGF2, FGFR1 | JAK1 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.