Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | ABL2 | P42684 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10138718 | 0.90 | CHRNB2 (0.36) | CHRM2CHRM1CHRM3GPR119UCHL1 | |
| SCHEMBL10138721 | 0.90 | UCHL1 (0.36) | CHRM2CHRM1CHRM3GPR119UCHL1 | |
| SCHEMBL15006984 | 0.90 | GPR119 (0.38) | CHRM2CHRM1CHRM3GPR119HDAC1 | |
| SCHEMBL15024919 | 0.89 | GPR119 (0.37) | PIK3CBPIK3CDPIK3CGMTORCHRM2 | |
| SCHEMBL10139707 | 0.87 | GPR119 (0.40) | CHRM2CHRM1CHRM3GPR119HDAC1 | |
| SCHEMBL15006726 | 0.86 | CHRNB2 (0.43) | CHRM2CHRM1CHRM3KCNK3KCNK9 | |
| SCHEMBL10139212 | 0.85 | CHRM2 (0.38) | PIK3CBPIK3CDPIK3CGMTORCHRM2 | |
| SCHEMBL10139708 | 0.85 | CHEK2 (0.42) | GPR119 | |
| SCHEMBL10138669 | 0.85 | CHRM2 (0.36) | CHRM2CHRM1CHRM3GPR119 | |
| SCHEMBL15024843 | 0.85 | WNT3A (0.42) | WNT3APIK3CBCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284322-B2 | Nicotinic receptor compounds | RESEARCH TRIANGLE INSTITUTE (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150152119-A1 | NICOTINIC RECEPTOR COMPOUNDS | RES TRIANGLE INST (US) | 2015-06-04 | — | — | US | disclosed |
| US-8981102-B2 | Nicotinic receptor compounds | RESEARCH TRIANGLE INSTITUTE (US) | 2015-03-17 | — | — | US | disclosed |
| US-20130150373-A1 | NICOTINIC RECEPTOR COMPOUNDS | RESEARCH TRIANGLE INSTITUTE (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150373-A1 | NICOTINIC RECEPTOR COMPOUNDS | CHRNG, CHRNA7, CHRNA2 | WNT3A 3151/4885PIK3CB 2099/4885PIK3CD 1997/4885 |
| US-20150152119-A1 | NICOTINIC RECEPTOR COMPOUNDS | CHRNG, CHRNA7, CHRNA2 | WNT3A 3151/4885PIK3CB 2099/4885PIK3CD 1997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.