Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 14/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994258 | 0.90 | SLC22A12 (0.50) | SLC22A12 | |
| SCHEMBL9994630 | 0.84 | DGAT1 (0.39) | SLC22A12IDO1 | |
| SCHEMBL15025886 | 0.73 | SLC22A12 (0.57) | SLC22A12 | |
| SCHEMBL15025968 | 0.72 | SLC22A12 (0.53) | SLC22A12 | |
| SCHEMBL12069098 | 0.72 | SLC22A12 (0.51) | SLC22A12 | |
| SCHEMBL15025919 | 0.71 | SLC22A12 (0.54) | SLC22A12 | |
| SCHEMBL15025979 | 0.70 | SLC22A12 (0.55) | SLC22A12 | |
| SCHEMBL20924043 | 0.70 | NOTUM (0.46) | NOTUMIDO1PTGS1PTGS2ALOX5AP | |
| SCHEMBL15025884 | 0.68 | SLC22A12 (0.57) | SLC22A12 | |
| SCHEMBL15677625 | 0.67 | FFAR4 (0.41) | NOTUMIDO1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212135-B2 | Phenylthioacetate compounds, compositions and methods of use | ARDEA BIOSCIENCES, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150322006-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. | 2015-11-12 | — | — | US | disclosed |
| US-20130150381-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCE, INC. (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150381-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MPST, PON1, NUDT1 | SLC22A12 628/4885NOTUM 1447/4885IRAK4 3625/4885 |
| US-20150322006-A1 | PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | PON1, NUDT1, HPRT1 | SLC22A12 450/4885NOTUM 1192/4885IRAK4 3310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.