Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | PRKDC | P78527 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764548 | 0.88 | MAOA (0.61) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL22337283 | 0.88 | ABCG2 (0.50) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL5470220 | 0.86 | HPRT1 (0.57) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL30154375 | 0.86 | HPRT1 (0.57) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL28398726 | 0.83 | MAOA (0.66) | ABCG2ABCC1KDM4EALDH1A1CYP1A1 | |
| SCHEMBL28402137 | 0.80 | KMT2A (0.55) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL22337130 | 0.80 | KMT2A (0.48) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL13085233 | 0.79 | HPRT1 (0.70) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL3081576 | 0.79 | ARSA (0.56) | ABCG2KMT2AABCC1KDM4EALDH1A1 | |
| SCHEMBL22326344 | 0.79 | KMT2A (0.47) | ABCG2KMT2AABCC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10305040-B2 | Spiro dihydroacridine derivatives and the use thereof as materials for organic electroluminescence devices | MERCK PATENT GMBH (DE) | 2019-05-28 | — | — | US | disclosed |
| EP-2780325-B1 | SPIRO-DIHYDROACRIDINE DERIVATIVES AND THEIR USE AS MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2016-02-03 | — | — | EP | disclosed |
| US-20140316134-A1 | SPIRO DIHYDROACRIDINE DERIVATIVES AND THE USE THEREOF AS MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2014-10-23 | — | — | US | disclosed |
| US-20140316134-A1 | SPIRO DIHYDROACRIDINE DERIVATIVES AND THE USE THEREOF AS MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2014-10-23 | — | — | US | disclosed |
| WO-2013083216-A1 | SPIRO DIHYDROACRIDINE DERIVATIVES AND THE USE THEREOF AS MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2013-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10305040-B2 | Spiro dihydroacridine derivatives and the use thereof as materials for organic electroluminescence devices | SORD, ALDH1A1, SDHA | ABCG2 899/4885KMT2A 3341/4885ABCC1 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.