Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15030823 | 0.97 | PDK2 (0.36) | PDK2CTSDBACE1ALDH1A1CYP3A4 | |
| SCHEMBL15030874 | 0.82 | ALDH1A1 (0.40) | ALDH1A1CYP3A4TSHRHSD17B10HPGD | |
| SCHEMBL15030887 | 0.80 | PDK2 (0.35) | PDK2CTSDBACE1CA12CA9 | |
| SCHEMBL15030672 | 0.80 | HTR7 (0.40) | PDK2CTSDBACE1ALDH1A1TSHR | |
| SCHEMBL15030835 | 0.79 | PDK2 (0.37) | PDK2CTSDBACE1CA12CA9 | |
| SCHEMBL15030803 | 0.78 | KDM4E (0.33) | ALDH1A1KMT2AMAPK1KDM4EATM | |
| SCHEMBL15030726 | 0.78 | PDK2 (0.38) | PDK2CTSDBACE1ALDH1A1TSHR | |
| SCHEMBL15030877 | 0.77 | KDM4E (0.33) | ALDH1A1KMT2AMEN1MAPK1KDM4E | |
| SCHEMBL15030729 | 0.76 | CTSD (0.33) | PDK2CTSDBACE1CA12CA9 | |
| SCHEMBL15030828 | 0.76 | CTSD (0.35) | PDK2CTSDBACE1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10305040-B2 | Spiro dihydroacridine derivatives and the use thereof as materials for organic electroluminescence devices | MERCK PATENT GMBH (DE) | 2019-05-28 | — | — | US | disclosed |
| EP-2780325-B1 | SPIRO-DIHYDROACRIDINE DERIVATIVES AND THEIR USE AS MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2016-02-03 | — | — | EP | disclosed |
| US-20140316134-A1 | SPIRO DIHYDROACRIDINE DERIVATIVES AND THE USE THEREOF AS MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2014-10-23 | — | — | US | disclosed |
| US-20140316134-A1 | SPIRO DIHYDROACRIDINE DERIVATIVES AND THE USE THEREOF AS MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2014-10-23 | — | — | US | disclosed |
| WO-2013083216-A1 | SPIRO DIHYDROACRIDINE DERIVATIVES AND THE USE THEREOF AS MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2013-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10305040-B2 | Spiro dihydroacridine derivatives and the use thereof as materials for organic electroluminescence devices | SORD, ALDH1A1, SDHA | PDK2 202/4885CTSD 1951/4885BACE1 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.