Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618609 | 0.77 | ATM (0.42) | TSHRALDH1A1KMT2A | |
| SCHEMBL6121157 | 0.69 | DRD2 (0.43) | FDPSSIRT3TDP1CYP11B1CYP11B2 | |
| SCHEMBL3855349 | 0.69 | — | — | |
| SCHEMBL30711624 | 0.67 | SIGMAR1 (0.39) | SIRT3TDP1ADORA3TSHRMC4R | |
| SCHEMBL19197111 | 0.67 | NAMPT (0.44) | SIRT3TDP1ADORA3TSHRMC4R | |
| SCHEMBL31618283 | 0.66 | CHRNB2 (0.35) | FDPSCHRNB2CHRNA4CHRNA7SIGMAR1 | |
| SCHEMBL31618365 | 0.66 | CHRNB2 (0.38) | FDPSCHRNB2CHRNA4CHRNA7SIGMAR1 | |
| SCHEMBL9520473 | 0.63 | ATM (0.35) | — | |
| SCHEMBL23212526 | 0.62 | MAPT (0.42) | FDPSSIRT3TDP1ADORA3TSHR | |
| SCHEMBL31412318 | 0.62 | P2RX7 (0.43) | SIRT3TDP1CYP11B1CYP11B2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | disclosed |