Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL150355 | 1.00 | ALDH1A1 (0.53) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL3730504 | 1.00 | ALDH1A1 (0.53) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Hydrochloric Acid SCHEMBL7673735 | 0.98 | ALDH1A1 (0.51) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Hydrochloric Acid SCHEMBL7679846 | 0.98 | ALDH1A1 (0.51) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Hydrochloric Acid SCHEMBL7673740 | 0.98 | ALDH1A1 (0.51) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL174568 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL2554077 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL3899366 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL354619 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL4495715 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180235909-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | GRUENENTHAL GMBH (DE) | 2018-08-23 | — | — | US | claimed |
| US-20160346228-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | GRUENENTHAL GMBH (DE) | 2016-12-01 | — | — | US | claimed |
| EP-3069717-A1 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING RHEUMATOID PAIN | Grünenthal GmbH (DE) | 2016-09-21 | — | — | EP | claimed |
| JP-4737583-B2 | — | — | 2011-08-03 | — | — | JP | claimed |
| US-20100311842-A1 | Use of 1-Phenyl-3-dimethylamino-propane Compounds for Treating Neuropathic Pain | GRUENENTHAL GMBH (DE) | 2010-12-09 | — | — | US | claimed |
| US-20100280128-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | GRUENENTHAL GMBH (DE) | 2010-11-04 | — | — | US | claimed |
| EP-2117525-A1 | USE OF 1-PHENYL-3-DIMETHYLAMINO-PROPANE COMPOUNDS FOR THE THERAPY OF NEUROPATHY PAIN | Grünenthal GmbH (DE) | 2009-11-18 | — | — | EP | claimed |
| US-20080269326-A1 | Use of 1-Phenyl-3-Dimethylamino-propane Compounds for Treating Neuropathic Pain | GRUENENTHAL GMBH (DE) | 2008-10-30 | — | — | US | claimed |
| WO-2008110323-A1 | USE OF 1-PHENYL-3-DIMETHYLAMINO-PROPANE COMPOUNDS FOR THE THERAPY OF NEUROPATHY PAIN | Grünenthal GmbH (DE) | 2008-09-18 | — | — | WO | claimed |
| EP-1438034-B1 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | GRUENENTHAL GMBH (DE) | 2008-07-30 | — | — | EP | claimed |
| EP-1438034-A2 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2004-07-21 | — | — | EP | claimed |
| EP-1429754-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2004047823-A1 | COMBINATION OF SELECTED ANALGESICS AND COX-II INHIBITORS | Grünenthal GmbH (DE) | 2004-06-10 | — | — | WO | claimed |
| EP-1390023-A2 | PHARMACEUTICAL SALTS | Grünenthal GmbH (DE) | 2004-02-25 | — | — | EP | claimed |
| US-20040034105-A1 | Use of 1-phenyl-3-dimethylaminopropane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2004-02-19 | — | — | US | claimed |
| WO-2003099268-A1 | COMBINATION OF SELECTED OPIOIDS WITH OTHER ACTIVE SUBSTANCES FOR USE IN THE THERAPY OF URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-12-04 | — | — | WO | claimed |
| WO-2003024444-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-03-27 | — | — | WO | claimed |
| WO-2002067916-A2 | PHARMACEUTICAL SALTS | Grünenthal GmbH (DE) | 2002-09-06 | — | — | WO | claimed |
| WO-2002067651-A2 | PHARMACEUTICAL SALTS | Grünenthal GmbH (DE) | 2002-09-06 | — | — | WO | claimed |
| WO-2002043715-A2 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2002-06-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269326-A1 | Use of 1-Phenyl-3-Dimethylamino-propane Compounds for Treating Neuropathic Pain | PMP22, GAP43, IAPP | ALDH1A1 598/4885CYP2D6 2870/4885CYP2C19 4686/4885 |
| US-20040034105-A1 | Use of 1-phenyl-3-dimethylaminopropane compounds for treatment of urinary incontinence | PNMT, UROD, PDE3A | ALDH1A1 32/4885CYP2D6 2039/4885CYP2C19 2940/4885 |
| US-20180235909-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | OPRK1, DRG1, OPRL1 | ALDH1A1 185/4885CYP2D6 1801/4885CYP2C19 4080/4885 |
| US-20100280128-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | OPRK1, DRG1, OPRL1 | ALDH1A1 185/4885CYP2D6 1801/4885CYP2C19 4080/4885 |
| US-20100311842-A1 | Use of 1-Phenyl-3-dimethylamino-propane Compounds for Treating Neuropathic Pain | PMP22, GAP43, IAPP | ALDH1A1 598/4885CYP2D6 2870/4885CYP2C19 4686/4885 |
| US-20160346228-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | OPRK1, DRG1, OPRL1 | ALDH1A1 185/4885CYP2D6 1801/4885CYP2C19 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.