Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3899366 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL3893895 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL4495715 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL2554077 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL174568 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| SCHEMBL3908680 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Hydrochloric Acid SCHEMBL7673673 | 0.99 | ALDH1A1 (0.49) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Hydrochloric Acid SCHEMBL7673668 | 0.99 | ALDH1A1 (0.49) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Cadaverine Tartrate SCHEMBL2551513 | 0.90 | LMNA (0.45) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 | |
| Cadaverine Tartrate SCHEMBL2551782 | 0.90 | LMNA (0.45) | ALDH1A1CYP2D6CYP2C19HSD17B10OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311842-A1 | Use of 1-Phenyl-3-dimethylamino-propane Compounds for Treating Neuropathic Pain | GRUENENTHAL GMBH (DE) | 2010-12-09 | — | — | US | claimed |
| US-20100280128-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | GRUENENTHAL GMBH (DE) | 2010-11-04 | — | — | US | claimed |
| EP-2117525-A1 | USE OF 1-PHENYL-3-DIMETHYLAMINO-PROPANE COMPOUNDS FOR THE THERAPY OF NEUROPATHY PAIN | Grünenthal GmbH (DE) | 2009-11-18 | — | — | EP | claimed |
| US-7550624-B2 | Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol and methods of using same | GRUENENTHAL GMBH (DE) | 2009-06-23 | — | — | US | claimed |
| WO-2008110323-A1 | USE OF 1-PHENYL-3-DIMETHYLAMINO-PROPANE COMPOUNDS FOR THE THERAPY OF NEUROPATHY PAIN | Grünenthal GmbH (DE) | 2008-09-18 | — | — | WO | claimed |
| EP-1438034-B1 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | GRUENENTHAL GMBH (DE) | 2008-07-30 | — | — | EP | claimed |
| EP-1509216-B1 | ACTIVE INGREDIENT SALTS AND ESTERS OF 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTAN-3-OL AND 3-(3-DIMETHYLAMINO-1-ETHYL-1-HYDROXY-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2008-05-07 | — | — | EP | claimed |
| EP-1429754-B1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | GRUENENTHAL GMBH (DE) | 2008-01-16 | — | — | EP | claimed |
| EP-1562567-A1 | COMBINATION OF SELECTED ANALGESICS AND COX-II INHIBITORS | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | claimed |
| US-20050143355-A1 | Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol and methods of using same | GRUENENTHAL GMBH (DE) | 2005-06-30 | — | — | US | claimed |
| US-6841575-B2 | Use of 1-phenyl-3-dimethylaminopropane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2005-01-11 | — | — | US | claimed |
| US-20040242617-A1 | active at very low doses, therefore low side effect profile | GRUENENTHAL GMBH (DE) | 2004-12-02 | — | — | US | claimed |
| EP-1438034-A2 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2004-07-21 | — | — | EP | claimed |
| EP-1429754-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2004047823-A1 | COMBINATION OF SELECTED ANALGESICS AND COX-II INHIBITORS | Grünenthal GmbH (DE) | 2004-06-10 | — | — | WO | claimed |
| US-20040034105-A1 | Use of 1-phenyl-3-dimethylaminopropane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2004-02-19 | — | — | US | claimed |
| WO-2003103650-A1 | ACTIVE INGREDIENT SALTS AND ESTERS OF 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTAN-3-OL AND 3-(3-DIMETHYLAMINO-1-ETHYL-1-HYDROXY-2-METHYL-PROPYL)-PHENOL | Grünenthal GmbH (DE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003099268-A1 | COMBINATION OF SELECTED OPIOIDS WITH OTHER ACTIVE SUBSTANCES FOR USE IN THE THERAPY OF URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-12-04 | — | — | WO | claimed |
| WO-2003024444-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-03-27 | — | — | WO | claimed |
| WO-2002043715-A2 | USE OF 1-PHENYL-3-DIMETHYLAMINOPROPANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2002-06-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242617-A1 | active at very low doses, therefore low side effect profile | OPRM1, OPRK1, OPRD1 | ALDH1A1 508/4885CYP2D6 808/4885CYP2C19 1431/4885 |
| US-20040034105-A1 | Use of 1-phenyl-3-dimethylaminopropane compounds for treatment of urinary incontinence | PNMT, UROD, PDE3A | ALDH1A1 32/4885CYP2D6 2039/4885CYP2C19 2940/4885 |
| US-20100280128-A1 | Use of 1-phenyl-3-dimethylaminopropane Compounds for Treating Rheumatoid Pain | OPRK1, DRG1, OPRL1 | ALDH1A1 185/4885CYP2D6 1801/4885CYP2C19 4080/4885 |
| US-20100311842-A1 | Use of 1-Phenyl-3-dimethylamino-propane Compounds for Treating Neuropathic Pain | PMP22, GAP43, IAPP | ALDH1A1 598/4885CYP2D6 2870/4885CYP2C19 4686/4885 |
| US-20050143355-A1 | Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol and methods of using same | MME, BPHL, AVPR2 | ALDH1A1 186/4885CYP2D6 675/4885CYP2C19 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.