Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6243674 | 0.72 | KCNH2 (0.50) | LOXL2CTSSCTSKKCNH2NR1H2 | |
| SCHEMBL3013574 | 0.71 | PTGS2 (0.44) | LOXL2CTSSCTSKKCNH2NR1H2 | |
| SCHEMBL612693 | 0.71 | BRD4 (0.41) | LOXL2CTSSCTSKKCNH2NR1H2 | |
| SCHEMBL1687505 | 0.69 | NR1H2 (0.52) | LOXL2KCNH2NR1H2NR1H3 | |
| SCHEMBL2140712 | 0.67 | PTGS2 (0.53) | LOXL2KCNH2NR1H2NR1H3PTGS2 | |
| SCHEMBL4827565 | 0.67 | DRD2 (0.53) | DRD2SIGMAR1 | |
| SCHEMBL4823982 | 0.67 | HTR2C (0.57) | SIGMAR1 | |
| SCHEMBL14538129 | 0.66 | ESR1 (0.37) | DRD2PTGS2 | |
| SCHEMBL3655415 | 0.66 | LOXL2 (0.54) | LOXL2KCNH2NR1H2LOX | |
| SCHEMBL18551802 | 0.66 | ALOX5 (0.42) | LOXL2CTSSCTSKKCNH2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604269-A1 | 1,4-benzodiazepine-2,5-diones with therapeutic properties | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-19 | — | — | EP | disclosed |