Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.54 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | LOX | P28300 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | NMT1 | P30419 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | CFD | P00746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 2/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127911 | 0.89 | HTR6 (0.51) | LOXL2USP28LOXHTR6ALDH1A1 | |
| SCHEMBL3727020 | 0.88 | ADAMTS4 (0.55) | USP28ADAMTS4NMT1PSIP1KIF11 | |
| Hydrochloric Acid SCHEMBL30468481 | 0.87 | LOXL2 (0.50) | LOXL2USP28LOXHTR6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL723559 | 0.87 | LOXL2 (0.50) | LOXL2USP28LOXHTR6ALDH1A1 | |
| SCHEMBL6243674 | 0.83 | KCNH2 (0.50) | LOXL2NR1H2KCNH2 | |
| SCHEMBL3791745 | 0.79 | LOXL2 (0.60) | LOXL2KLKB1CFD | |
| Trifluoroacetic Acid SCHEMBL15758512 | 0.78 | DPP4 (0.51) | LOXL2USP28ADAMTS4NR1H2KLKB1 | |
| SCHEMBL2140712 | 0.77 | PTGS2 (0.53) | LOXL2HTR6NR1H2KCNH2ALDH1A1 | |
| SCHEMBL3649075 | 0.77 | PLA2G10 (0.44) | LOXL2NR1H2KCNH2ALDH1A1GAA | |
| SCHEMBL14320520 | 0.77 | CA12 (0.58) | LOXL2USP28KCNH2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205556-A2 | BIARYL SULFONAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040289-A2 | BIARYL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |
| US-20090088459-A1 | NOVEL BIARYL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088459-A1 | NOVEL BIARYL SULFONAMIDE DERIVATIVES | NR1H3, NR1H2, NR1H4 | LOXL2 2373/4885USP28 3732/4885ADAMTS4 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.