Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15047763 | 0.79 | CYP1A2 (0.47) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL26953360 | 0.78 | CYP1A2 (0.46) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL30060833 | 0.78 | CYP1A2 (0.46) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL23467159 | 0.74 | CYP1A2 (0.50) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL12269968 | 0.73 | CYP1A2 (0.49) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL3330957 | 0.72 | PORCN (0.42) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL17796572 | 0.71 | CYP1A2 (0.47) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL17654918 | 0.71 | CYP1A2 (0.47) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL13086631 | 0.71 | CYP11B2 (0.40) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 | |
| SCHEMBL15950989 | 0.71 | COMT (0.60) | CYP2D6CYP1A2CYP3A4CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754226-B2 | Piperidinyl-substituted lactams as GPR119 modulators | ARRAY BIOPHARMA INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20130158009-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA, INC. | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158009-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | GPR119, GPR139, GPR39 | CYP2D6 2299/4885CYP1A2 1115/4885CYP3A4 2459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.