Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 10/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504682 | 0.85 | ADAM17 (0.41) | ALDH1A1SMN1; SMN2CA1CA2KDM4E | |
| SCHEMBL1504843 | 0.80 | ADAM17 (0.48) | ALDH1A1LMNATSHRSMN1; SMN2SLC6A9 | |
| SCHEMBL10476069 | 0.80 | ADAM17 (0.48) | ALDH1A1LMNATSHRSMN1; SMN2SLC6A9 | |
| SCHEMBL1503521 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TSHRSMN1; SMN2GAAKDM4E | |
| SCHEMBL1503536 | 0.77 | KMT2A (0.49) | ALDH1A1LMNATSHRSMN1; SMN2KDM4E | |
| SCHEMBL1504776 | 0.73 | ADAM17 (0.63) | — | |
| SCHEMBL1504674 | 0.71 | ADAM17 (0.61) | ALDH1A1 | |
| SCHEMBL1504528 | 0.70 | ADAM17 (0.62) | ALDH1A1 | |
| SCHEMBL1504857 | 0.70 | ADAM17 (0.64) | ALDH1A1KDM4E | |
| SCHEMBL1504727 | 0.67 | TAS1R3 (0.49) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |