Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503521 | 0.87 | ALDH1A1 (0.47) | KMT2AMAPTTSHRSMN1; SMN2POLB | |
| SCHEMBL1504682 | 0.81 | ADAM17 (0.41) | KMT2AMAPTSMN1; SMN2POLBKDM4E | |
| SCHEMBL2680363 | 0.78 | LMNA (0.49) | KMT2AMAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1504817 | 0.77 | ALDH1A1 (0.44) | TSHRSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL10475931 | 0.73 | ADAM17 (0.53) | KMT2AMAPTTSHRSMN1; SMN2POLB | |
| SCHEMBL10475932 | 0.73 | ADAM17 (0.53) | KMT2AMAPTTSHRSMN1; SMN2POLB | |
| SCHEMBL28644461 | 0.70 | SMN1; SMN2 (0.58) | KMT2AMAPTTSHRSMN1; SMN2POLB | |
| SCHEMBL1503616 | 0.69 | CTSK (0.45) | KMT2AMAPTTSHRSMN1; SMN2KDM4E | |
| SCHEMBL24550972 | 0.69 | RAB9A (0.58) | KMT2AMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL18289780 | 0.69 | RAB9A (0.58) | KMT2AMAPTTSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033010-A1 | 4-ALKOXY-N- (2-HYDROXYCARBAMOYL-2-PIPERIDINYL-ETHYL) -BENZAMIDE COMPOUNDS AS SELECTIVE TACE-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |