SCHEMBL150516

SCHEMBL150516

O=C(Oc1ccccc1-c1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.61
MAPT P10636 3/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
SLC6A3 Q01959 1/20 0.59
TDP1 Q9NUW8 3/20 0.57
L3MBTL1 Q9Y468 3/20 0.57
TOP1 P11387 1/20 0.57
ESR1 P03372 2/20 0.53
ESR2 Q92731 2/20 0.53
HSD17B10 Q99714 2/20 0.53
MEN1 O00255 1/20 0.53
JAK2 O60674 1/20 0.53
USP2 O75604 1/20 0.53
GAA P10253 1/20 0.53
ALOX15 P16050 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
RXRA P19793 1/20 0.53
RXRB P28702 1/20 0.53
RXRG P48443 1/20 0.53
FABP7 O15540 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28123080 0.96 RXRA (0.57) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
Hydrogen Sulfide SCHEMBL27779483 0.91 KMT2A (0.56) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL31517375 0.90 KMT2A (0.68) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL27898043 0.90 RXRA (0.55) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL11761673 0.87 KMT2A (0.50) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL2484009 0.86 TOP1 (0.55) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL27717755 0.84 SLC6A3 (0.55) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL725404 0.83 KMT2A (0.76) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL11761665 0.83 LMNA (0.57) KMT2AMAPTSMN1; SMN2SLC6A3TDP1
SCHEMBL30563023 0.82 FABP3 (0.56) MAPTSMN1; SMN2TDP1L3MBTL1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 258 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021011538-A1 CAPSULE DOSAGE FORMS, METHODS OF PREPARATION AND METHODS OF USE THEREOF R.P. SCHERER TECHNOLOGIES, LLC (US) 2021-01-21 WO claimed
JP-54078382-A None JP disclosed
US-20240239759-A1 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS INTERVET INC. (US) 2024-07-18 US disclosed
CN-117986154-A Antiparasitic compounds 英特维特国际股份有限公司 2024-05-07 CN disclosed
EP-4284509-A1 ANTIPARASITIC COMPOUNDS Intervet International B.V. (NL) 2023-12-06 EP disclosed
CN-116964031-A Antiparasitic compounds 英特维特国际股份有限公司 2023-10-27 CN disclosed
CN-113166064-B Cholinesterase inhibitor polymorph and application thereof 长春华洋高科技有限公司 2023-04-11 CN disclosed
EP-2545777-B2 Use of an isoxazoline composition as antiparasitic INTERVET INT BV (NL) 2023-01-18 EP disclosed
US-20220033539-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2022-02-03 US disclosed
US-20220000814-A1 METHODS FOR TREATMENT OF PRADER-WILLI SYNDROME YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) 2022-01-06 US disclosed
WO-1992016206-A1 THE USE OF 5-AMINOSALICYLIC ACID IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME - DIARRHEAL PHASE OR TYPE (IBS-D) NORWICH EATON PHARMACEUTICALS INC. (US) 1992-10-01 WO disclosed
WO-1992016214-A1 THE USE OF 5-AMINOSALICYLIC ACID IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME - DIARRHEAL PHASE OR TYPE (IBS-D) NORWICH EATON PHARMACEUTICALS INC. (US) 1992-10-01 WO disclosed
US-5102576-A Quick response properties CHISSO CORPORATION (JP) 1992-04-07 US disclosed
WO-1991017746-A1 THE USE OF PHENYLPROPANOLAMINE AS A MUCUS SECRETAGOGUE IN THE UPPER AIRWAYS NORWICH EATON PHARMACEUTICALS, INC. (US) 1991-11-28 WO disclosed
EP-0427195-A2 A ferroelectric liquid crystal composition Chisso Corporation (JP) 1991-05-15 EP disclosed
EP-0371448-A2 Ferroelectric liquid crystal composition and liquid crystal display element Chisso Corporation (JP) 1990-06-06 EP disclosed
US-4882086-A HIGH SPEED LIGHT SWITCHES CHISSO CORPORATION (JP) 1989-11-21 US disclosed
EP-0328330-A2 Ferroelectric liquid crystal composition CHISSO CORPORATION (JP) 1989-08-16 EP disclosed
EP-0083886-A1 Organic compound of the triple substituted biphenylyl benzoate type and process for its preparation THOMSON-CSF (FR) 1983-07-20 EP disclosed
JP-S5478382-A LIQUID CRYSTAL COMPOSITION ASAHI GLASS CO LTD 1979-06-22 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220000814-A1 METHODS FOR TREATMENT OF PRADER-WILLI SYNDROME MECP2, BHMT2, EBP KMT2A 99/4885MAPT 3652/4885SMN1; SMN2 271/4885
US-20240239759-A1 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS PRDX5, TUBA3C, TUBA1C KMT2A 799/4885MAPT 3469/4885SMN1; SMN2 4269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.