Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054889 | 0.84 | TNF (0.43) | SMN1; SMN2ALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL25262955 | 0.74 | ACHE (0.44) | LMNASMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL30258024 | 0.74 | ACHE (0.44) | LMNASMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL16427427 | 0.74 | NPC1 (0.38) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL14251705 | 0.72 | HDAC6 (0.39) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14249020 | 0.72 | NPC1 (0.36) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL14249825 | 0.71 | PRPS1 (0.46) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL3374705 | 0.71 | LMNA (0.55) | LMNAALDH1A1KMT2ARXFP1GAA | |
| SCHEMBL2431491 | 0.70 | KDM4E (0.43) | LMNASMN1; SMN2ALDH1A1MAPK1NPC1 | |
| SCHEMBL25374507 | 0.70 | KDM4E (0.46) | SMN1; SMN2ALDH1A1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096151-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |