SCHEMBL15527635

SCHEMBL15527635

CC(CC#Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)O)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 11/20 0.41
FOLR1 P15328 2/20 0.41
SLC19A1 P41440 2/20 0.41
SLC46A1 Q96NT5 2/20 0.41
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
HSD17B10 Q99714 2/20 0.40
KDM4E B2RXH2 1/20 0.37
TLR4 O00206 1/20 0.37
MEN1 O00255 1/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.37
TYMS P04818 1/20 0.37
GLA P06280 1/20 0.37
POLB P06746 1/20 0.37
HMGB1 P09429 1/20 0.37
MAPT P10636 1/20 0.37
FOLR2 P14207 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15054330 0.78 DHFR (0.39) DHFRFOLR1SLC19A1SLC46A1ALDH1A1
SCHEMBL13529660 0.72 DHFR (0.70) DHFRFOLR1SLC19A1SLC46A1
SCHEMBL9542097 0.72 DHFR (0.69) DHFRFOLR1SLC19A1SLC46A1ALDH1A1
SCHEMBL15075303 0.71 DHFR (0.54) DHFRFOLR1SLC19A1SLC46A1
SCHEMBL15055069 0.70 NOS1 (0.35) DHFRALDH1A1HPGDHSD17B10MEN1
SCHEMBL23028940 0.68 ADORA2A (0.46) MEN1MAPTBLMKMT2A
SCHEMBL11629266 0.68 DHFR (0.65) DHFR
SCHEMBL24344752 0.68 DHFR (0.65) DHFR
SCHEMBL221621 0.67 DHFR (0.71) DHFRFOLR1SLC19A1SLC46A1ALDH1A1
SCHEMBL29658170 0.67 DHFR (0.71) DHFRFOLR1SLC19A1SLC46A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013164856-A1 A PROCESS FOR PREPARING INTERMEDIATES OF 10-PROPARGYL-10-DEAZAAMINOPTERIN (PRALATREXATE) SYNTHESIS AND THE INTERMEDIATES THEREOF AVRA LABORATORIES PRIVATE LIMITED (IN) 2013-11-07 WO claimed
WO-2013164856-A1 A PROCESS FOR PREPARING INTERMEDIATES OF 10-PROPARGYL-10-DEAZAAMINOPTERIN (PRALATREXATE) SYNTHESIS AND THE INTERMEDIATES THEREOF AVRA LABORATORIES PRIVATE LIMITED (IN) 2013-11-07 WO disclosed