Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15056430 | 0.85 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL2156854 | 0.78 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL30482895 | 0.78 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL29184272 | 0.76 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| Ag1295 SCHEMBL925674 | 0.76 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL30846532 | 0.76 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL8499222 | 0.74 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL18885991 | 0.73 | BCHE (0.61) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL16968755 | 0.73 | ALDH1A1 (0.56) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB | |
| SCHEMBL16968754 | 0.73 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2FLT3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797417-B1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIV DUESSELDORF (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | HEINRICH HEINE UNIVERSITAT DUSSELDORF (DE) | 2015-08-06 | — | — | US | disclosed |
| EP-2797417-A1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | Heinrich-Heine-Universität Düsseldorf (DE) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013093007-A1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | CBR3, GRHPR, PCK1 | NPC1 3014/4885RAB9A 4437/4885SMN1; SMN2 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.