Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ACACA | Q13085 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6339578 | 0.96 | KDM4E (0.92) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL30696080 | 0.96 | KDM4E (0.92) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL12062005 | 0.85 | ALDH1A1 (0.76) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL31070199 | 0.85 | KDM4E (0.74) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL8009508 | 0.85 | KDM4E (0.74) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL8112450 | 0.85 | KDM4E (0.74) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL14211963 | 0.85 | KDM4E (0.73) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL12341701 | 0.84 | ALDH1A1 (0.71) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL12964202 | 0.84 | KMT2A (0.73) | KDM4EL3MBTL1LMNAALDH1A1TDP1 | |
| SCHEMBL15561039 | 0.84 | LMNA (0.72) | KDM4EL3MBTL1LMNAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797417-B1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIV DUESSELDORF (DE) | 2019-07-31 | — | — | EP | disclosed |
| EP-2797417-B1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIV DUESSELDORF (DE) | 2019-07-31 | — | — | EP | disclosed |
| CN-105693632-B | A kind of preparation method of polysubstituted quinoxaline derivant | 华侨大学 | 2018-04-17 | — | — | CN | disclosed |
| CN-105693632-A | Preparation method of polysubstitution quinoxalin derivatives | 华侨大学 | 2016-06-22 | — | — | CN | disclosed |
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | HEINRICH HEINE UNIVERSITAT DUSSELDORF (DE) | 2015-08-06 | — | — | US | disclosed |
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | HEINRICH HEINE UNIVERSITAT DUSSELDORF (DE) | 2015-08-06 | — | — | US | disclosed |
| EP-2797417-A1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | Heinrich-Heine-Universität Düsseldorf (DE) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013093007-A1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093007-A1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | CBR3, GRHPR, PCK1 | KDM4E 559/4885L3MBTL1 2001/4885LMNA 4654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.