Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27627484 | 0.84 | ALDH1A1 (0.47) | APPUSP2ALDH1A1CYP1A2SMN1; SMN2 | |
| SCHEMBL157611 | 0.74 | L3MBTL1 (0.53) | HSD17B10KMT2AGAAMEN1RAB9A | |
| SCHEMBL5309397 | 0.72 | ALOX5 (0.48) | CYP1A2SMN1; SMN2RAB9A | |
| SCHEMBL8600426 | 0.71 | DDB1 (0.43) | APPUSP2ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL30979853 | 0.70 | ALDH1A1 (0.54) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL1180429 | 0.69 | ABL1 (0.83) | HDAC4HDAC2HDAC8APPABL1 | |
| SCHEMBL20702773 | 0.67 | CA12 (0.42) | APPALDH1A1KMT2AGAATDP1 | |
| SCHEMBL9796089 | 0.67 | ALOX5 (0.45) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL27760027 | 0.67 | EGFR (0.49) | USP2ALDH1A1CYP1A2SMN1; SMN2MAPK1 | |
| SCHEMBL11730124 | 0.66 | CD274 (0.68) | APPALDH1A1CYP1A2SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793881-A1 | ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME | The Regents of the University of Colorado (US) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013096820-A1 | ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2013-06-27 | — | — | WO | disclosed |