SCHEMBL15058042

SCHEMBL15058042

CC(C)(C)OC(=O)NCCCCCNC(=O)CSC1CC(=O)N(c2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)C1=O

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ FOLH1 Q04609 1/20 0.44
▸ USP2 O75604 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ FKBP1A P62942 3/20 0.43
▸ CA9 Q16790 6/20 0.43
▸ CA12 O43570 5/20 0.43
▸ CA1 P00915 5/20 0.43
▸ CA2 P00918 5/20 0.43
▸ ALB P02768 2/20 0.42
▸ ESR1 P03372 1/20 0.42
▸ HTR3A P46098 2/20 0.40
▸ CA14 Q9ULX7 2/20 0.40
▸ CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15057677 0.91 USP2 (0.48) FOLH1USP2L3MBTL1CA9CA12
SCHEMBL14586590 0.83 USP2 (0.55) USP2L3MBTL1CA9CA12CA1
SCHEMBL12706329 0.80 USP2 (0.58) USP2L3MBTL1CA9CA12CA1
SCHEMBL14415288 0.79 FOLH1 (0.49) FOLH1USP2L3MBTL1CA9CA12
SCHEMBL12134945 0.77 USP2 (0.60) USP2L3MBTL1CA9CA12CA1
SCHEMBL20276070 0.75 USP2 (0.58) USP2L3MBTL1CA9CA12CA1
SCHEMBL15144330 0.73 USP2 (0.38) USP2L3MBTL1FKBP1ACA9CA12
SCHEMBL22651493 0.72 USP2 (0.68) USP2L3MBTL1CA9CA12CA1
SCHEMBL12652583 0.71 USP2 (0.47) USP2L3MBTL1FKBP1ACA9CA12
SCHEMBL12262227 0.71 ALB (0.52) FOLH1USP2L3MBTL1CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2793947-B1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2021-02-03 — — EP disclosed
US-10675359-B2 Enzymatic conjugation of antibodies INNATE PHARMA (FR) 2020-06-09 — — US disclosed
EP-3564259-A2 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION Innate Pharma (FR) 2019-11-06 — — EP disclosed
US-10434180-B2 Enzymatic conjugation of polypeptides INNATE PHARMA (FR) 2019-10-08 — — US disclosed
US-20190169601-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION INNATE PHARMA (FR) 2019-06-06 — — US disclosed
EP-2872894-B1 SCREENING OF CONJUGATED ANTIBODIES INNATE PHARMA (FR) 2019-04-17 — — EP disclosed
EP-3240573-B1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2019-03-20 — — EP disclosed
EP-2793949-B1 ENZYMATIC CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2018-08-22 — — EP disclosed
US-10036010-B2 Recognition tags for TGase-mediated conjugation INNATE PHARMA (FR) 2018-07-31 — — US disclosed
US-20180193476-A1 ENZYMATIC CONJUGATION OF ANTIBODIES ARARIS BIOTECH LTD (CH) 2018-07-12 — — US disclosed
EP-2872894-A2 SCREENING OF CONJUGATED ANTIBODIES Innate Pharma (FR) 2015-05-20 — — EP disclosed
WO-2014202775-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2014-12-24 — — WO disclosed
US-20140356385-A1 ENZYMATIC CONJUGATION OF ANTIBODIES ARARIS BIOTECH LTD (CH) 2014-12-04 — — US disclosed
EP-2793949-A1 ENZYMATIC CONJUGATION OF ANTIBODIES Innate Pharma (FR) 2014-10-29 — — EP disclosed
EP-2793947-A2 ENZYMATIC CONJUGATION OF POLYPEPTIDES Innate Pharma (FR) 2014-10-29 — — EP disclosed
WO-2014072482-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION INNATE PHARMA (FR) 2014-05-15 — — WO disclosed
WO-2014009426-A2 SCREENING OF CONJUGATED ANTIBODIES INNATE PHARMA (FR) 2014-01-16 — — WO disclosed
US-20130189287-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES PAUL SCHERRER INSTITUT 2013-07-25 — — US disclosed
WO-2013092983-A2 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2013-06-27 — — WO disclosed
WO-2013092998-A1 ENZYMATIC CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2013-06-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10675359-B2 Enzymatic conjugation of antibodies DNPEP, MPO, FCGR3B FOLH1 124/4885USP2 862/4885L3MBTL1 4099/4885
US-20180193476-A1 ENZYMATIC CONJUGATION OF ANTIBODIES DNPEP, MPO, FCGR3B FOLH1 124/4885USP2 862/4885L3MBTL1 4099/4885
US-20130189287-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES DNPEP, ENPEP, PEPD FOLH1 65/4885USP2 893/4885L3MBTL1 3868/4885
US-10434180-B2 Enzymatic conjugation of polypeptides DNPEP, ENPEP, PEPD FOLH1 77/4885USP2 841/4885L3MBTL1 3802/4885
US-10036010-B2 Recognition tags for TGase-mediated conjugation TGM2, TGM3, TGM6 FOLH1 22/4885USP2 1141/4885L3MBTL1 1846/4885
US-20140356385-A1 ENZYMATIC CONJUGATION OF ANTIBODIES DNPEP, MPO, FCGR3B FOLH1 124/4885USP2 862/4885L3MBTL1 4099/4885
US-20190169601-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION TGM2, TGM3, TGM6 FOLH1 22/4885USP2 1141/4885L3MBTL1 1846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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