Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28451507 | 0.83 | POLB (0.56) | ADRB2ADRB1ADRB3POLBKMT2A | |
| SCHEMBL254773 | 0.80 | CES1 (0.65) | POLBKMT2AMEN1MAPK1CES1 | |
| SCHEMBL1857541 | 0.79 | MAPK1 (0.56) | POLBKMT2AMEN1MAPK1CES1 | |
| Methylamine SCHEMBL29169653 | 0.79 | TSHR (0.60) | POLBKMT2AMEN1MAPK1CES1 | |
| SCHEMBL1733955 | 0.78 | MGLL (0.57) | KMT2AMEN1MAPK1NR1H4PKM | |
| SCHEMBL27866766 | 0.78 | POLB (0.62) | ADRB2ADRB1ADRB3POLBKMT2A | |
| SCHEMBL20448111 | 0.78 | ALDH1A1 (0.47) | POLBKMT2AMEN1MAPK1CES1 | |
| SCHEMBL5389258 | 0.77 | MAPK1 (0.63) | POLBKMT2AMEN1MAPK1CES1 | |
| SCHEMBL27487269 | 0.77 | POLB (0.50) | ADRB2ADRB1ADRB3POLBKMT2A | |
| SCHEMBL306161 | 0.77 | POLB (0.81) | POLBKMT2AMEN1MAPK1CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794603-B1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-06-15 | — | — | EP | disclosed |
| US-9181248-B2 | [1,2,4]triazolopyridines and their use as phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-11-10 | — | — | US | disclosed |
| US-20150105420-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | UNION therapeutics A/S (DK) | 2015-04-16 | — | — | US | disclosed |
| US-8940761-B2 | [1,2,4]triazolopyridines and their use as phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2015-01-27 | — | — | US | disclosed |
| US-20140329853-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | UNION therapeutics A/S (DK) | 2014-11-06 | — | — | US | disclosed |
| EP-2794603-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092739-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329853-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3A, PDE2A | ADRB2 289/4885ADRB1 243/4885ADRB3 308/4885 |
| US-20150105420-A1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3A, PDE2A | ADRB2 289/4885ADRB1 243/4885ADRB3 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.