Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10535020 | 0.82 | ADORA2B (0.47) | PDE1APDE1BPDE1CPDE2AADORA2B | |
| SCHEMBL28956705 | 0.81 | PDE2A (0.39) | PDE1APDE1BPDE1CPDE2AADORA2B | |
| SCHEMBL6363706 | 0.77 | ADORA1 (0.48) | ADORA2BADORA3SIRT1SIRT3SIRT5 | |
| SCHEMBL14142760 | 0.77 | ADORA2B (0.57) | ADORA2BADORA3ADORA2A | |
| SCHEMBL5646 | 0.75 | PDE2A (0.61) | PDE1APDE1BPDE1CPDE2AADORA2B | |
| SCHEMBL2917587 | 0.75 | PDE1A (0.78) | PDE1APDE1BPDE1CPDE2AADORA2B | |
| SCHEMBL60158 | 0.74 | ADORA2A (0.70) | PDE1APDE1BPDE1CPDE2AADORA2B | |
| SCHEMBL1946619 | 0.74 | ADORA2B (0.65) | ADORA2BADORA3ADORA2A | |
| SCHEMBL387340 | 0.73 | ADORA2B (0.55) | PDE1APDE1BPDE1CPDE2AADORA2B | |
| SCHEMBL1460912 | 0.73 | PDE1A (0.58) | PDE1APDE1BPDE1CPDE2ASIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 911 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1912109-B | Structural method and application of tissue engineering adipose tissue | INST TRANSFUSION MEDICINE ACADEMY MILITARY MEDICAL SCIENCES | 2010-09-15 | — | — | CN | claimed |
| US-20100184212-A1 | HUMAN EMBRYONIC STEM CELL DERIVED MESODERM-LIKE EPITHELIUM TRANSITIONS TO MESENCHYMAL PROGENITOR CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., THE | 2010-07-22 | — | — | US | claimed |
| US-20090028830-A1 | Preparation of multipotent stem cells and the use thereof | LIU YUNG-HSIANG | 2009-01-29 | — | — | US | claimed |
| WO-2008150498-A1 | HUMAN EMBRYONIC STEM CELL DERIVED MESODERM-LIKE EPITHELIUM TRANSITIONS TO MESENCHYMAL PROGENITOR CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. (US) | 2008-12-11 | — | — | WO | claimed |
| CN-101085983-A | Autologous stem cell, target cell transformed therefrom and its uses | YONGXIANG LIU (CN) | 2007-12-12 | — | — | CN | claimed |
| CN-1912110-A | Method and application of induced differentiating fat originate stem cells to adipocyte | FEILD FLOOD TRANSFUSION INST A (CN) | 2007-02-14 | — | — | CN | claimed |
| CN-1912109-A | Structural method and application of tissue engineering adipose tissue | FEILD BLOOD TRANSFUSION INST A (CN) | 2007-02-14 | — | — | CN | claimed |
| EP-0954565-B1 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | OSIRIS THERAPEUTICS INC (US) | 2006-10-11 | — | — | EP | claimed |
| EP-1659172-A1 | Adipogenic differentiation of human mesenchymal stem cells | Osiris Therapeutics, Inc. (US) | 2006-05-24 | — | — | EP | claimed |
| US-20050192349-A1 | Isolation of the peroxisome proliferation-activated receptor-gamma (PPARgamma) ligand and methods of use thereof | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2005-09-01 | — | — | US | claimed |
| WO-2004001052-A1 | ISOLATION OF THE PEROXISOME PROLIFERATION-ACTIVATED RECEPTOR-GAMMA (PPARη) LIGAND AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2003-12-31 | — | — | WO | claimed |
| EP-0954565-A4 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | OSIRIS THERAPEUTICS INC (US) | 2002-09-18 | — | — | EP | claimed |
| US-6322784-B1 | GLUCOCORTICOID, A COMPOUND WHICH STIMULATES CAMP PRODUCTION AND COMPOUND WHICH UPREGULATES PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR .GAMMA. EXPRESSION | OSIRIS THERAPEUTICS, INC. | 2001-11-27 | — | — | US | claimed |
| EP-0954565-A1 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | Osiris Therapeutics, Inc. (US) | 1999-11-10 | — | — | EP | claimed |
| US-5827740-A | Adipogenic differentiation of human mesenchymal stem cells | OSIRIS THERAPEUTICS, INC. (US) | 1998-10-27 | — | — | US | claimed |
| EP-0403139-B1 | Cell culture sytems and media | ORGANOGENESIS INC (US) | 1998-08-12 | — | — | EP | claimed |
| WO-1998004682-A1 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | OSIRIS THERAPEUTICS, INC. (US) | 1998-02-05 | — | — | WO | claimed |
| US-5712163-A | Chemically defined cell culture media and system and methods for use, particularly for culturing epithelial cells | ORGANOGENESIS, INC. (US) | 1998-01-27 | — | — | US | claimed |
| EP-0403139-A1 | Cell culture sytems and media | ORGANOGENESIS INC. (US) | 1990-12-19 | — | — | EP | claimed |
| US-4456687-A | CULTURES; CYCLIC ADENOSINE-3'-PHOSPHATE STIMULANTS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1984-06-26 | — | — | US | claimed |