Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 6/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24442343 | 0.73 | PIK3CD (0.52) | RPS6KA3PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15070791 | 0.73 | MEN1 (0.43) | NQO2CDC7CCNA2CDK2CCNA1 | |
| SCHEMBL28849703 | 0.68 | KMT2A (0.46) | MAPK1NPSR1CDC7RPS6KA3CCNA2 | |
| SCHEMBL27884299 | 0.68 | NQO2 (0.51) | NQO2CDC7CCNA2CDK2CCNA1 | |
| SCHEMBL12906820 | 0.67 | RAB9A (0.52) | CDC7CCNA2CDK2CCNA1BRD4 | |
| SCHEMBL25891692 | 0.66 | GAA (0.47) | NPSR1CDK2CDK1GSK3BKDM4E | |
| SCHEMBL1536003 | 0.66 | NOTUM (0.56) | NPSR1NQO2KDM4EHSD17B10NPC1 | |
| SCHEMBL7452411 | 0.65 | MLKL (0.40) | MAPK1NPSR1CDC7RPS6KA3CCNA2 | |
| SCHEMBL8684331 | 0.64 | MAPK1 (0.63) | MAPK1NPSR1RPS6KA3IKBKBJAK2 | |
| SCHEMBL17883343 | 0.64 | KDM4E (0.74) | NQO2CDC7CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | MAPK1 1586/4885NPSR1 3196/4885NQO2 1469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.