Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16133080 | 0.82 | HRH2 (0.41) | HRH2HRH1CTSBCTSS | |
| SCHEMBL317200 | 0.81 | TSHR (0.47) | HRH2HRH1CYP1A2TDP1 | |
| SCHEMBL317199 | 0.81 | TSHR (0.47) | HRH2HRH1CYP1A2TDP1 | |
| SCHEMBL30484009 | 0.78 | HTR1A (0.46) | HRH2HRH1CYP1A2TDP1HSD17B10 | |
| SCHEMBL16197319 | 0.78 | CYP1A2 (0.45) | CYP1A2TDP1HSD17B10CHRM1HTR1A | |
| SCHEMBL14843166 | 0.78 | CYP1A2 (0.45) | CYP1A2TDP1HSD17B10CHRM1HTR1A | |
| SCHEMBL15247207 | 0.78 | HRH2 (0.43) | HRH2HRH1 | |
| SCHEMBL15247210 | 0.78 | HRH2 (0.43) | HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL3402044 | 0.77 | CYP1A2 (0.43) | CYP1A2TDP1HSD17B10CHRM1HTR1A | |
| SCHEMBL524811 | 0.75 | LMNA (0.49) | HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794618-B1 | ISOTHIAZOLOPYRIDINE-2-CARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2016-11-16 | — | — | EP | disclosed |
| US-9260454-B2 | Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals | SANOFI (FR) | 2016-02-16 | — | — | US | disclosed |
| US-20140296169-A1 | ISOTHIAZOLOPYRIDINE-2-CARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2014-10-02 | — | — | US | disclosed |
| WO-2013092574-A1 | ISOTHIAZOLOPYRIDINE-2-CARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296169-A1 | ISOTHIAZOLOPYRIDINE-2-CARBOXAMIDES AND THEIR USE AS PHARMACEUTICALS | TGM2, TGM1, TGM6 | HRH2 84/4885HRH1 345/4885CYP1A2 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.