Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14868433 | 0.84 | ALOX15 (0.43) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL14868412 | 0.75 | KDM4E (0.41) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL14868383 | 0.70 | ALOX15 (0.42) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL11271935 | 0.68 | KDM4E (0.44) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL22373636 | 0.66 | LMNA (0.37) | — | |
| SCHEMBL31572011 | 0.65 | TDP1 (0.55) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL11793624 | 0.64 | SMN1; SMN2 (0.55) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL25540950 | 0.64 | ALDH1A1 (0.59) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| SCHEMBL14868431 | 0.62 | ALOX15 (0.41) | KDM4EMEN1RGS12USP2ALDH1A1 | |
| Metformin Xr SCHEMBL4210659 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013103384-A1 | BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS | ELCELYX THERAPEUTICS, INC. (US) | 2013-07-11 | — | — | WO | disclosed |