Sugi Predict

Sugi Predict / Compounds / SCHEMBL1513422

SCHEMBL1513422

SCHEMBL1513422

Brc1ccc(OC[C@@H]2CO2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.66
▸ ALDH1A1 P00352 5/20 0.61
▸ TSHR P16473 4/20 0.61
▸ MAPT P10636 4/20 0.61
▸ TP53 P04637 3/20 0.61
▸ HPGD P15428 2/20 0.61
▸ HIF1A Q16665 2/20 0.61
▸ MEN1 O00255 2/20 0.61
▸ KMT2A Q03164 2/20 0.61
▸ PKM P14618 2/20 0.61
▸ LMNA P02545 2/20 0.61
▸ CYP1A2 P05177 1/20 0.61
▸ PPARG P37231 1/20 0.61
▸ GAA P10253 1/20 0.61
▸ CYP3A4 P08684 2/20 0.58
▸ SMN1; SMN2 Q16637 1/20 0.58
▸ KDM4E B2RXH2 1/20 0.47
▸ GLA P06280 1/20 0.46
▸ FGFR1 P11362 1/20 0.41
▸ SRC P12931 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17592769 1.00 TDP1 (0.66) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL1513424 1.00 TDP1 (0.66) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL11742399 0.94 TDP1 (0.59) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL21094081 0.89 TDP1 (0.79) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL50264 0.89 TDP1 (0.79) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL20677146 0.89 TDP1 (0.79) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL6295754 0.87 ALDH1A1 (0.85) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL11378097 0.86 TDP1 (0.68) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL21638946 0.84 TDP1 (0.66) TDP1ALDH1A1TSHRMAPTTP53
SCHEMBL2527785 0.84 ALDH1A1 (0.59) TDP1ALDH1A1TSHRMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119552109-A MyD88 inhibitor and application thereof 杭州医学院 2025-03-04 — — CN disclosed
CN-119219616-A Pyridine amide derivative and application thereof 石家庄迪斯凯威医药科技有限公司 2024-12-31 — — CN disclosed
EP-4373809-A1 SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS Novartis AG (CH) 2024-05-29 — — EP disclosed
CN-117980292-A Substituted pyridone compounds for the treatment of orthomyxoviral infections 诺华股份有限公司 2024-05-03 — — CN disclosed
WO-2023002443-A1 SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS NOVARTIS AG (CH) 2023-01-26 — — WO disclosed
WO-2023002443-A1 SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS NOVARTIS AG (CH) 2023-01-26 — — WO disclosed
EP-3191454-B1 CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2018-10-24 — — EP disclosed
US-9938222-B2 Cyclopropanecarboxylic acid GPR120 modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2018-04-10 — — US disclosed
US-9938222-B2 Cyclopropanecarboxylic acid GPR120 modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2018-04-10 — — US disclosed
US-9938222-B2 Cyclopropanecarboxylic acid GPR120 modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2018-04-10 — — US disclosed
US-20170327457-A1 PHENYL-(AZA)CYCLOALKYL CARBOXYLIC ACID GPR120 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2017-11-16 — — US disclosed
US-20170253554-A1 CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2017-09-07 — — US disclosed
US-20170253554-A1 CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2017-09-07 — — US disclosed
US-20170253554-A1 CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS BRISTOL MYERS SQUIBB CO (US) 2017-09-07 — — US disclosed
EP-2137193-B1 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF SANOFI SA (FR) 2017-08-09 — — EP disclosed
US-8642603-B2 Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof SANOFI (FR) 2014-02-04 — — US disclosed
WO-2011034828-A1 SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF SANOFI-AVENTIS (FR) 2011-03-24 — — WO disclosed
US-20100075994-A1 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF SANOFI-AVENTIS (FR) 2010-03-25 — — US disclosed
EP-2137193-A2 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF Sanofi-Aventis (FR) 2009-12-30 — — EP disclosed
WO-2008112483-A2 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF SANOFI-AVENTIS (FR) 2008-09-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100075994-A1 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF GRM2, GRM1, GRIN2C TDP1 1955/4885ALDH1A1 1875/4885TSHR 513/4885
US-20170253554-A1 CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS GPR88, GPBAR1, GPR68 TDP1 4814/4885ALDH1A1 2321/4885TSHR 991/4885
US-20170327457-A1 PHENYL-(AZA)CYCLOALKYL CARBOXYLIC ACID GPR120 MODULATORS GPR88, GPR55, GPR180 TDP1 4810/4885ALDH1A1 1360/4885TSHR 640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.