Sugi Predict

Sugi Predict / Compounds / SCHEMBL1521278

SCHEMBL1521278

SCHEMBL1521278

CC(=O)C(N)(N)CC(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HMGCR P04035 1/20 0.43
▸ CHRM1 P11229 1/20 0.43
▸ TBXA2R P21731 1/20 0.43
▸ ADRA1A P35348 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42
▸ CYP2C19 P33261 2/20 0.42
▸ HIF1A Q16665 2/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ THRB P10828 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ FFAR1 O14842 1/20 0.37
▸ CPT2 P23786 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ FFAR3 O14843 2/20 0.33
▸ GLRA1 P23415 1/20 0.33
▸ SLC6A9 P48067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7173083 0.78 LMNA (0.37) KDM4ECYP2C19ALDH1A1CYP1A2TDP1
SCHEMBL468400 0.77 ALDH1A1 (0.48) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL681316 0.74 ALDH1A1 (0.39) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL681237 0.74 ALDH1A1 (0.56) KDM4EHIF1ACYP2D6TSHRALDH1A1
SCHEMBL22612007 0.74 HIF1A (0.44) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL11872169 0.74 HIF1A (0.44) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL5973422 0.72 ALDH1A1 (0.38) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL20360428 0.71 HMGCR (0.48) HMGCRCHRM1TBXA2RADRA1AKDM4E
SCHEMBL84219 0.71 — —
SCHEMBL9536247 0.71 HMGCR (0.55) HMGCRCHRM1TBXA2RADRA1AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110212890-A1 METASTIN DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-09-01 — — US claimed
EP-2314609-A1 METASTIN DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2011-04-27 — — EP claimed
JP-4653840-B2 — — 2011-03-16 — — JP claimed
US-20110059888-A1 METASTIN DERIVATIVES AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-03-10 — — US claimed
US-20090298765-A1 Metastin derivatives and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-12-03 — — US claimed
EP-2113513-A2 Metastin derivatives and use thereof Takeda Pharmaceutical Company Limited (JP) 2009-11-04 — — EP claimed
US-20090215700-A1 Metastin derivatives and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-08-27 — — US claimed
EP-2081955-A1 METASTIN DERIVATIVES AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2009-07-29 — — EP claimed
JP-2009520682-A — — 2009-05-28 — — JP claimed
US-20090105152-A1 METASTIN DERIVATIVES AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-04-23 — — US claimed
CN-101341168-A Metastin derivatives and use thereof TAKEDA PHARMACEUTICAL (JP) 2009-01-07 — — CN claimed
US-20080312155-A1 Metastin Derivatives and Use Thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-12-18 — — US claimed
EP-1963362-A1 METASTIN DERIVATIVES AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2008-09-03 — — EP claimed
WO-2008050897-A1 METASTIN DERIVATIVES AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-05-02 — — WO claimed
WO-2007072997-A1 METASTIN DERIVATIVES AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-06-28 — — WO claimed
CN-115919996-A Adiponectin peptidomimetics for the treatment of ophthalmic diseases 雅利斯塔制药公司 2023-04-07 — — CN disclosed
EP-3210998-A1 METASTIN DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2017-08-30 — — EP disclosed
WO-2006001499-A2 METASTIN DERIVATIVES AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-01-05 — — WO disclosed
US-20040116336-A1 Peptide derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-06-17 — — US disclosed
EP-1270585-A1 PEPTIDE DERIVATIVE Takeda Chemical Industries, Ltd. (JP) 2003-01-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215700-A1 Metastin derivatives and use thereof SHBG, GNRHR, INHA HMGCR 3171/4885CHRM1 3291/4885TBXA2R 2983/4885
US-20080312155-A1 Metastin Derivatives and Use Thereof GNRHR, SHBG, MEN1 HMGCR 3265/4885CHRM1 3288/4885TBXA2R 3749/4885
US-20110059888-A1 METASTIN DERIVATIVES AND USE THEREOF SHBG, GNRHR, INHA HMGCR 3171/4885CHRM1 3291/4885TBXA2R 2983/4885
US-20090298765-A1 Metastin derivatives and use thereof GNRHR, SHBG, MEN1 HMGCR 3265/4885CHRM1 3288/4885TBXA2R 3749/4885
US-20110212890-A1 METASTIN DERIVATIVE AND USE THEREOF GNRHR, SHBG, LHCGR HMGCR 4311/4885CHRM1 4271/4885TBXA2R 4114/4885
US-20090105152-A1 METASTIN DERIVATIVES AND USE THEREOF SHBG, GNRHR, INHA HMGCR 2919/4885CHRM1 3362/4885TBXA2R 2757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.