Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 1/20 | 0.73 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TGM2 | P21980 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 4/20 | 0.60 |
| ▸ | MMP2 | P08253 | 4/20 | 0.60 |
| ▸ | MMP9 | P14780 | 4/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.52 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14578749 | 0.92 | NMT1 (0.85) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL5177468 | 0.85 | NMT1 (1.00) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL9351727 | 0.85 | NMT1 (1.00) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL5177395 | 0.85 | NMT1 (1.00) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL5177391 | 0.83 | DDAH1 (1.00) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL13113092 | 0.83 | TGM2 (0.59) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL15693012 | 0.83 | DDAH1 (0.54) | NMT1DDAH1ALDH1A1MMP1MMP2 | |
| SCHEMBL5177465 | 0.83 | DDAH1 (1.00) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL11797311 | 0.82 | TGM2 (0.69) | NMT1DDAH1ALDH1A1TGM2MMP1 | |
| SCHEMBL6587982 | 0.82 | NMT1 (0.70) | NMT1DDAH1ALDH1A1TGM2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150238472-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-08-27 | — | — | US | disclosed |
| US-9011882-B2 | Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-04-21 | — | — | US | disclosed |
| US-20130224259-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150238472-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | DDAH1, DIMT1, PADI1 | NMT1 565/4885DDAH1 1/4885ALDH1A1 563/4885 |
| US-20130224259-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | DDAH1, DIMT1, PADI1 | NMT1 565/4885DDAH1 1/4885ALDH1A1 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.