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Sugi Predict / Compounds / SCHEMBL5177468

SCHEMBL5177468

SCHEMBL5177468

Cc1ccc(NC(=O)/C=C\C(=O)O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NMT1 P30419 1/20 1.00
▸ LPAR2 Q9HBW0 2/20 0.72
▸ LPAR3 Q9UBY5 1/20 0.72
▸ ALDH1A1 P00352 8/20 0.72
▸ POLB P06746 2/20 0.72
▸ DDAH1 O94760 1/20 0.71
▸ MAPT P10636 5/20 0.70
▸ L3MBTL1 Q9Y468 2/20 0.70
▸ GAA P10253 2/20 0.70
▸ TDP2 O95551 1/20 0.70
▸ THRB P10828 1/20 0.70
▸ LMNA P02545 1/20 0.67
▸ NR4A1 P22736 1/20 0.67
▸ SMN1; SMN2 Q16637 2/20 0.66
▸ KDM4E B2RXH2 2/20 0.66
▸ MMP1 P03956 2/20 0.65
▸ MMP2 P08253 2/20 0.65
▸ MMP9 P14780 2/20 0.65
▸ EGFR P00533 1/20 0.65
▸ KMT2A Q03164 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5177395 1.00 NMT1 (1.00) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL9351727 1.00 NMT1 (1.00) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL8467779 0.95 NMT1 (0.90) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL8467780 0.95 NMT1 (0.90) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL14578749 0.92 NMT1 (0.85) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL23966420 0.90 ALDH1A1 (0.84) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL22862256 0.90 NMT1 (0.81) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL11133691 0.90 LPAR2 (0.88) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL11137034 0.90 LPAR2 (0.88) NMT1LPAR2LPAR3ALDH1A1POLB
SCHEMBL15693860 0.85 NMT1 (0.73) NMT1LPAR2LPAR3ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0403240-B1 Preparation process of N-substituted maleimides MITSUI TOATSU CHEMICALS (JP) 1994-08-24 — — EP claimed
EP-0372922-B1 Preparation process of N-substituted maleimides MITSUI TOATSU CHEMICALS (JP) 1994-03-09 — — EP claimed
US-5175309-A Forming an imide by heat catalytic dehydration MITSUI TOATSU CHEMICALS INC. (JP) 1992-12-29 — — US claimed
US-5068357-A Heat dehydration of an N-substituted maleamic acid with a solvent, distillation after imidation, in the presence of a tin catalyst MITSUI TOATSU CHEMICALS, INC. (JP) 1991-11-26 — — US claimed
EP-0403240-A1 Preparation process of N-substituted maleimides MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-12-19 — — EP claimed
EP-0372922-A2 Preparation process of N-substituted maleimides MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-06-13 — — EP claimed
CN-116209716-A Processing aid for vinyl chloride resin composition 株式会社钟化 2023-06-02 — — CN disclosed
US-20160297828-A1 SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO ACID RESIDUES ZAGORII GLEB VLADIMIROVICH (UA) 2016-10-13 — — US disclosed
CN-104977808-A Black photosensitive resin composite and black matrix made from the black photosensitive resin composite DONGWOO FINE CHEM CO LTD 2015-10-14 — — CN disclosed
US-20150031663-A1 PHTHALANILATE COMPOUNDS AND METHODS OF USE UNIVERSITY OF NOTRE DAME DU LAC (US) 2015-01-29 — — US disclosed
US-8859620-B2 Phthalanilate compounds and methods of use UNIVERSITY OF NOTRE DAME DU LAC (US) 2014-10-14 — — US disclosed
US-20120232150-A1 PHTHALANILATE COMPOUNDS AND METHODS OF USE University of Nortre Dame du Lac 2012-09-13 — — US disclosed
EP-1602481-B1 Lithographic printing plate precursor FUJIFILM CORP (JP) 2007-05-30 — — EP disclosed
US-4970323-A Preparation process of N-substituted monochlorosuccinimides MITSUI TOATSU CHEMICALS, INC. (JP) 1990-11-13 — — US disclosed
EP-0372922-A2 Preparation process of N-substituted maleimides MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-06-13 — — EP disclosed
EP-0349259-A1 Preparation process of N-substituted monochlorosuccinimide MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-01-03 — — EP disclosed
US-4225498-A Preparation of N-substituted oligo-imides RHONE-POULENC INDUSTRIES (FR) 1980-09-30 — — US disclosed
US-4225497-A ACID CATALYSTS FOR IMIDATION RHONE-POULENC INDUSTRIES (FR) 1980-09-30 — — US disclosed
US-4179444-A Process for the manufacture of iso-imides or mixtures of iso-imides and imides CIBA-GEIGY CORPORATION (US) 1979-12-18 — — US disclosed
US-4125398-A N-Phenyl-maleic acid amides for regulating the growth and development of plants CIBA-GEIGY CORPORATION (US) 1978-11-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160297828-A1 SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO ACID RESIDUES CRHR1, NR3C1, MC2R NMT1 3571/4885LPAR2 1601/4885LPAR3 1298/4885
US-20120232150-A1 PHTHALANILATE COMPOUNDS AND METHODS OF USE MPO, ALPI, NQO1 NMT1 1529/4885LPAR2 3646/4885LPAR3 1982/4885
US-20150031663-A1 PHTHALANILATE COMPOUNDS AND METHODS OF USE MPO, ALPI, NQO1 NMT1 1529/4885LPAR2 3646/4885LPAR3 1982/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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