Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 1/20 | 1.00 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.72 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | TDP2 | O95551 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MMP1 | P03956 | 2/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | MMP9 | P14780 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177395 | 1.00 | NMT1 (1.00) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL5177468 | 1.00 | NMT1 (1.00) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL8467779 | 0.95 | NMT1 (0.90) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL8467780 | 0.95 | NMT1 (0.90) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL14578749 | 0.92 | NMT1 (0.85) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL23966420 | 0.90 | ALDH1A1 (0.84) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL22862256 | 0.90 | NMT1 (0.81) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL11133691 | 0.90 | LPAR2 (0.88) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL11137034 | 0.90 | LPAR2 (0.88) | NMT1LPAR2LPAR3ALDH1A1POLB | |
| SCHEMBL15693860 | 0.85 | NMT1 (0.73) | NMT1LPAR2LPAR3ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160297828-A1 | SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO ACID RESIDUES | ZAGORII GLEB VLADIMIROVICH (UA) | 2016-10-13 | — | — | US | disclosed |
| CN-1724532-A | Colorant compound | XEROX CORP (US) | 2006-01-25 | — | — | CN | disclosed |
| EP-0349259-B1 | Preparation process of N-substituted monochlorosuccinimide | MITSUI TOATSU CHEMICALS (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-4970323-A | Preparation process of N-substituted monochlorosuccinimides | MITSUI TOATSU CHEMICALS, INC. (JP) | 1990-11-13 | — | — | US | disclosed |
| US-4902746-A | Use of mixtures of polycarbonates and styrene polymers as substrates for optical storage media | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-20 | — | — | US | disclosed |
| EP-0349259-A1 | Preparation process of N-substituted monochlorosuccinimide | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-01-03 | — | — | EP | disclosed |
| US-4225498-A | Preparation of N-substituted oligo-imides | RHONE-POULENC INDUSTRIES (FR) | 1980-09-30 | — | — | US | disclosed |
| US-4225497-A | ACID CATALYSTS FOR IMIDATION | RHONE-POULENC INDUSTRIES (FR) | 1980-09-30 | — | — | US | disclosed |
| US-4179444-A | Process for the manufacture of iso-imides or mixtures of iso-imides and imides | CIBA-GEIGY CORPORATION (US) | 1979-12-18 | — | — | US | disclosed |
| US-4125398-A | N-Phenyl-maleic acid amides for regulating the growth and development of plants | CIBA-GEIGY CORPORATION (US) | 1978-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297828-A1 | SPIROCYCLIC COMPOUNDS CONTAINING SPIRO[INDOLYL-3,1'-PYRROLO[3,4-C]PYRROLE] CORE AND SULPHUR-CONTAINING AMINO ACID RESIDUES | CRHR1, NR3C1, MC2R | NMT1 3571/4885LPAR2 1601/4885LPAR3 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.