Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | PKM | P14618 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15213964 | 0.87 | ALDH1A1 (1.00) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL8806385 | 0.75 | PKM (0.53) | ALDH1A1KDM4ESMN1; SMN2MAPTPKM | |
| SCHEMBL9538809 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL13680866 | 0.75 | ALDH1A1 (0.60) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL10050008 | 0.73 | ALDH1A1 (0.57) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL14793048 | 0.72 | ALDH1A1 (0.47) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL2466643 | 0.71 | ALDH1A1 (1.00) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL16921274 | 0.71 | ALDH1A1 (0.73) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL18177326 | 0.71 | ALDH1A1 (1.00) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL28429884 | 0.70 | ALDH1A1 (0.84) | ALDH1A1KDM4ECYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150238472-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2015-08-27 | — | — | US | disclosed |
| US-9011882-B2 | Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-04-21 | — | — | US | disclosed |
| US-20130224259-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150238472-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | DDAH1, DIMT1, PADI1 | ALDH1A1 563/4885KDM4E 1401/4885CYP1A2 185/4885 |
| US-20130224259-A1 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof | DDAH1, DIMT1, PADI1 | ALDH1A1 563/4885KDM4E 1401/4885CYP1A2 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.