Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15230900 | 0.83 | LMNA (0.37) | MAPTLMNAMALT1ALDH1A1GAA | |
| SCHEMBL15230495 | 0.68 | PDE10A (0.41) | MAPTLMNAMALT1ALDH1A1KMT2A | |
| SCHEMBL6946111 | 0.58 | SMN1; SMN2 (0.44) | MAPTLMNAALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL19477824 | 0.57 | TSHR (0.41) | MAPTLMNAALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL11650241 | 0.57 | TSHR (0.50) | LMNAALDH1A1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL11650240 | 0.56 | ALDH1A1 (0.47) | MAPTLMNAALDH1A1KMT2AGAA | |
| SCHEMBL16735359 | 0.56 | MAPT (0.49) | MAPTLMNAALDH1A1KMT2AHPGD | |
| SCHEMBL17665629 | 0.55 | LMNA (0.55) | MAPTLMNAALDH1A1KMT2AGAA | |
| SCHEMBL8728841 | 0.54 | LMNA (0.53) | MAPTLMNAALDH1A1KMT2AL3MBTL1 | |
| Dibutyl Phthalate SCHEMBL8167118 | 0.54 | TSHR (0.76) | LMNAALDH1A1L3MBTL1SMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2820006-A1 | PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS | ChemoCentryx, Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130811-A1 | PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2013-09-06 | — | — | WO | disclosed |