Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15209818 | 0.86 | PDE10A (0.42) | PDE10AMAPTHTTKMT2AALDH1A1 | |
| SCHEMBL21882083 | 0.81 | PDE10A (0.49) | PDE10AMAPTHTTKMT2AALDH1A1 | |
| SCHEMBL15209864 | 0.79 | PDE10A (0.47) | PDE10AMAPTHTTKMT2AALDH1A1 | |
| SCHEMBL20028705 | 0.72 | ALDH1A1 (0.46) | PDE10AMAPTHTTKMT2AALDH1A1 | |
| SCHEMBL15209882 | 0.71 | SLC9A1 (0.41) | MAPTHTTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15230900 | 0.70 | LMNA (0.37) | MAPTALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL15232733 | 0.70 | SLC9A1 (0.45) | MAPTHTTKMT2AALDH1A1MEN1 | |
| SCHEMBL6314486 | 0.69 | SLC9A1 (0.65) | MAPTALDH1A1RAB9ASLC9A1HPGD | |
| SCHEMBL15218575 | 0.68 | NPY5R (0.50) | MAPTHTTKMT2AALDH1A1MEN1 | |
| SCHEMBL15230609 | 0.68 | MAPT (0.35) | MAPTKMT2AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2820006-A1 | PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS | ChemoCentryx, Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130811-A1 | PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2013-09-06 | — | — | WO | disclosed |