Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15209227 | 0.83 | MALT1 (0.35) | MALT1 | |
| SCHEMBL15230609 | 0.83 | MAPT (0.35) | LMNAMAPTMALT1ALDH1A1BCHE | |
| SCHEMBL15230495 | 0.70 | PDE10A (0.41) | LMNAMAPTMALT1RAB9AKDM4E | |
| SCHEMBL15209827 | 0.65 | MALT1 (0.36) | MALT1 | |
| SCHEMBL19477824 | 0.58 | TSHR (0.41) | LMNAMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL11650241 | 0.57 | TSHR (0.50) | LMNAKDM4EALDH1A1TSHRBCHE | |
| SCHEMBL7402250 | 0.57 | RAB9A (0.48) | LMNAMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL11650240 | 0.57 | ALDH1A1 (0.47) | LMNAMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL15233727 | 0.56 | ESR1 (0.48) | LMNAMAPTRAB9AKDM4ETSHR | |
| SCHEMBL7454057 | 0.56 | TSHR (0.40) | LMNAMAPTRAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2820006-A1 | PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS | ChemoCentryx, Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| WO-2013130811-A1 | PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR9 ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2013-09-06 | — | — | WO | disclosed |