Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 9/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | AGXT | P21549 | 6/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646907 | 0.86 | IDO1 (0.42) | CYP3A4IDO1FFAR4AGXTTAAR1 | |
| SCHEMBL3059636 | 0.79 | IDO1 (0.34) | ALDH1A1IDO1 | |
| SCHEMBL8750484 | 0.78 | IDO1 (0.60) | ALDH1A1IDO1TAAR1MAOA | |
| SCHEMBL10819591 | 0.78 | ENPP2 (0.50) | CYP3A4TAAR1 | |
| SCHEMBL10226540 | 0.78 | TP53 (0.39) | ALDH1A1IDO1FFAR4AGXTTAAR1 | |
| SCHEMBL231203 | 0.78 | IDO1 (0.41) | IDO1AGXT | |
| SCHEMBL13412791 | 0.77 | IDO1 (0.58) | CYP3A4ALDH1A1CYP2C19IDO1AGXT | |
| SCHEMBL19354499 | 0.77 | SLC2A1 (0.37) | CYP3A4ALDH1A1CYP2C19IDO1FFAR4 | |
| SCHEMBL17214612 | 0.77 | ENPP2 (0.48) | CYP3A4ALDH1A1IDO1MRGPRX4 | |
| SCHEMBL10314841 | 0.77 | CYP3A4 (0.58) | CYP3A4IDO1AGXTTAAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2647644-B1 | 2'-O-MODIFIED RNA | WAVE LIFE SCIENCES JAPAN INC (JP) | 2020-09-09 | — | — | EP | disclosed |
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |
| US-8822671-B2 | 2'-O-modified RNA | THE UNIVERSITY OF TOKYO (JP) | 2014-09-02 | — | — | US | disclosed |
| EP-2647644-A1 | 2'-O-MODIFIED RNA | Chiralgen, Ltd. (JP) | 2013-10-09 | — | — | EP | disclosed |
| US-20130253178-A1 | 2'-O-MODIFIED RNA | THE UNIVERSITY OF TOKYO (JP) | 2013-09-26 | — | — | US | disclosed |
| CN-100582087-C | 2-amino-bicyclo [3.1.0] hexane-2, 6-dicarboxylic acid ester derivatives | TAISHO PHARMACEUTICAL CO LTD | 2010-01-20 | — | — | CN | disclosed |
| CN-1812960-A | 2-amino-bicyclo [3.1.0] hexane-2, 6-dicarboxylic acid ester derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-08-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130253178-A1 | 2'-O-MODIFIED RNA | METTL16, NSUN2, METTL3 | CYP3A4 3776/4885ALDH1A1 1555/4885CYP2C19 3809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.