Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | BID | P55957 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313684 | 0.88 | HSP90AA1 (0.47) | MAPTBCL2MCL1MEN1KMT2A | |
| SCHEMBL15313682 | 0.77 | RAB9A (0.51) | NPC1RAB9AALDH1A1HTTL3MBTL1 | |
| SCHEMBL5698161 | 0.72 | BCL2 (0.58) | MAPTALDH1A1L3MBTL1BCL2MCL1 | |
| SCHEMBL16203111 | 0.72 | NPC1 (0.70) | NPC1RAB9AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL15313690 | 0.71 | BCL2 (0.43) | NPC1MAPTALDH1A1HTTBCL2 | |
| SCHEMBL16203113 | 0.70 | TDP1 (0.61) | NPC1RAB9AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL9448569 | 0.70 | BCL2 (0.55) | MAPTALDH1A1L3MBTL1BCL2MCL1 | |
| SCHEMBL7394259 | 0.69 | TDP1 (0.61) | NPC1RAB9AMAPTALDH1A1L3MBTL1 | |
| SCHEMBL3949047 | 0.69 | PARP1 (0.57) | NPC1RAB9AMAPTALDH1A1HTT | |
| SCHEMBL29817934 | 0.69 | NPC1 (0.84) | NPC1RAB9AALDH1A1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |