Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.50 |
| ▸ | BCL2 | P10415 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313684 | 0.84 | HSP90AA1 (0.47) | MCL1BCL2LMNAKMT2APOLB | |
| SCHEMBL15313692 | 0.77 | NPC1 (0.48) | RAB9ANPC1MCL1BCL2HTT | |
| SCHEMBL15313690 | 0.73 | BCL2 (0.43) | NPC1MCL1BCL2HTTALDH1A1 | |
| SCHEMBL5698161 | 0.71 | BCL2 (0.58) | MCL1BCL2ALDH1A1L3MBTL1CYP2C9 | |
| SCHEMBL5826355 | 0.71 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2LMNAPKM | |
| SCHEMBL15313790 | 0.69 | BCL2 (0.58) | RAB9ASMN1; SMN2BCL2LMNAHTT | |
| SCHEMBL9448569 | 0.69 | BCL2 (0.55) | MCL1BCL2ALDH1A1L3MBTL1CYP2C9 | |
| SCHEMBL15313687 | 0.69 | SIGMAR1 (0.43) | BCL2KMT2AGABRA1 | |
| SCHEMBL15313693 | 0.69 | BCL2 (0.68) | MCL1BCL2POLB | |
| SCHEMBL10070199 | 0.68 | USP5 (0.65) | RAB9ANPC1SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |