Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.67 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313887 | 0.84 | BCL2 (0.56) | BCL2MAOABCL2L1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15313847 | 0.81 | BCL2 (1.00) | BCL2BCL2L1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15313875 | 0.76 | MAOA (0.47) | MAOASMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL15313898 | 0.75 | MAOA (0.46) | MAOASMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL15313820 | 0.75 | BCL2 (1.00) | BCL2BCL2L1ALDH1A1LMNAKMT2A | |
| SCHEMBL15313885 | 0.73 | MAOA (0.44) | MAOASMN1; SMN2ALDH1A1LMNAKMT2A | |
| SCHEMBL4869345 | 0.71 | CA12 (0.68) | MAOASMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL3157891 | 0.70 | GPR3 (0.53) | BCL2MAOABCL2L1KMT2ACHEK1 | |
| SCHEMBL28707306 | 0.70 | PTPN1 (0.73) | BCL2BCL2L1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313853 | 0.69 | BCL2 (0.77) | BCL2BCL2L1SMN1; SMN2TP53ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |