Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14780598 | 0.84 | ALDH1A1 (0.40) | TPH1EGFRALDH1A1MEN1LMNA | |
| SCHEMBL8208523 | 0.83 | TPH1 (0.62) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL287073 | 0.83 | TPH1 (0.62) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL31614353 | 0.83 | TPH1 (0.62) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL30969128 | 0.83 | TPH1 (0.62) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL287095 | 0.83 | TPH1 (0.62) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL14780599 | 0.79 | SLC7A5 (0.58) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL8884067 | 0.78 | SLC7A5 (0.54) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL8884063 | 0.78 | SLC7A5 (0.54) | TPH1HSD17B10SLC7A5PTGS1PKM | |
| SCHEMBL3576640 | 0.76 | EGFR (0.49) | HSD17B10PTGS1EGFRKDM4EADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586988-B2 | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides | AMBRX, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-8557781-B2 | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides | AMBRX, INC. (US) | 2013-10-15 | — | — | US | disclosed |