Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL333847 | 0.93 | GAA (0.63) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL15906664 | 0.84 | GAA (0.57) | GAABRD4HSD17B10 | |
| SCHEMBL11045652 | 0.81 | GAA (0.57) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL13593675 | 0.81 | GAA (0.53) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL11041593 | 0.77 | GAA (0.51) | GAABRD4CYP3A4MAPTKMT2A | |
| SCHEMBL11044416 | 0.74 | BRD4 (0.45) | GAABRD4CYP3A4MAPTKMT2A | |
| SCHEMBL9214465 | 0.72 | GAA (0.55) | GAA | |
| SCHEMBL8268993 | 0.72 | GAA (0.51) | GAA | |
| SCHEMBL11038245 | 0.69 | GAA (0.53) | GAA | |
| SCHEMBL7951439 | 0.68 | GAA (0.48) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013150544-A2 | IVABRADINE HYDROCHLORIDE SOLID DISPERSION | HETERO RESEARCH FOUNDATION (IN) | 2013-10-10 | — | — | WO | disclosed |