Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL15319252 | 0.93 | GAA (0.56) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL28634068 | 0.89 | GAA (0.58) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL15906664 | 0.88 | GAA (0.57) | GAABRD4ALDH1A1MAOAACHE | |
| SCHEMBL11045652 | 0.88 | GAA (0.57) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL13593675 | 0.84 | GAA (0.53) | GAABRD4CYP3A4MAPTCRHBP | |
| SCHEMBL11041593 | 0.83 | GAA (0.51) | GAABRD4CYP3A4MAPTKMT2A | |
| SCHEMBL11044416 | 0.80 | BRD4 (0.45) | GAABRD4CYP3A4MAPTKMT2A | |
| SCHEMBL30468397 | 0.78 | GAA (1.00) | GAASRCALDH1A1MAOAACHE | |
| SCHEMBL9214465 | 0.77 | GAA (0.55) | GAA | |
| SCHEMBL11038245 | 0.75 | GAA (0.53) | GAAGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114324715-B | Detection method of related substances in 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-06-02 | — | — | CN | claimed |
| CN-114324715-A | Method for detecting related substances in 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-112946143-A | Analysis and detection method of 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2021-06-11 | — | — | CN | claimed |
| CN-111187211-A | Preparation method of dimer impurity in ivabradine hydrochloride intermediate | 北京鑫开元医药科技有限公司海南分公司 | 2020-05-22 | — | — | CN | claimed |
| WO-2017138017-A1 | PROCESS FOR THE PREPARATION OF BENZAZEPINE-2-ONE DERIVATIVE | IND-SWIFT LABORATORIES LIMITED (IN) | 2017-08-17 | — | — | WO | claimed |
| WO-2014020534-A1 | IVABRADINE HYDROCHLORIDE AND THE PROCESSES FOR PREPARATION THEREOF | BIOCON LIMITED (IN) | 2014-02-06 | — | — | WO | claimed |
| CN-114324715-B | Detection method of related substances in 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-114324715-B | Detection method of related substances in 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-112946143-B | Analysis and detection method of 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-112946143-B | Analysis and detection method of 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-114324715-A | Method for detecting related substances in 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-112946143-A | Analysis and detection method of 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzazepin-2-ketone | 海南鑫开源医药科技有限公司 | 2021-06-11 | — | — | CN | disclosed |
| EP-2135861-B2 | Process for the synthesis of the 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and its application to the synthesis of ivabradine as well as its addition salts with a pharmaceutically acceptable acid | SERVIER LAB (FR) | 2020-12-16 | — | — | EP | disclosed |
| EP-0116444-A2 | Improvements in or relating to benzazepine derivatives | ELI LILLY AND COMPANY (US) | 1984-08-22 | — | — | EP | disclosed |
| EP-0109636-A2 | Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds | Dr. Karl Thomae GmbH (DE) | 1984-05-30 | — | — | EP | disclosed |
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
| EP-0065229-A1 | Benzazepines, process for their preparation and their application as pharmaceutical preparations | Dr. Karl Thomae GmbH (DE) | 1982-11-24 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |