SCHEMBL15323282

SCHEMBL15323282

COc1ccc(N=C(C)c2ccc(OC)cc2)cc1.[Ir]

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 3/20 0.62
HTR3E A5X5Y0 1/20 0.57
HTR3B O95264 1/20 0.57
HTR3A P46098 1/20 0.57
HTR3D Q70Z44 1/20 0.57
HTR3C Q8WXA8 1/20 0.57
MAPT P10636 4/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
MEN1 O00255 1/20 0.50
MAPK1 P28482 1/20 0.50
KMT2A Q03164 1/20 0.50
PRSS1 P07477 1/20 0.50
ACR P10323 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 2/20 0.49
LMNA P02545 1/20 0.49
NFKB1 P19838 1/20 0.49
CASP3 P42574 1/20 0.49
NFKB2 Q00653 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15323278 1.00 NOS3 (0.62) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL24105687 0.98 NOS3 (0.64) NOS3HTR3EHTR3BHTR3AHTR3D
Hydrochloric Acid SCHEMBL23795043 0.94 NOS3 (0.60) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL15323965 0.91 RAB9A (0.54) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL15323964 0.91 RAB9A (0.54) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL15322907 0.91 NOS3 (0.56) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL15322903 0.91 NOS3 (0.56) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL23795045 0.91 NOS3 (0.56) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL18025541 0.89 RAB9A (0.56) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL16373407 0.89 HPGD (0.56) NOS3HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12491503-B2 Hydrogenation process of oxime derivatives SYNGENTA CROP PROTECTION AG (CH) 2025-12-09 US disclosed
US-20210387173-A1 HYDROGENATION PROCESS OF OXIME DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-12-16 US disclosed
EP-2836497-B1 CATALYST COMPOUNDS UNIV LIVERPOOL (GB) 2016-03-23 EP disclosed
US-9212199-B2 Catalyst compounds THE UNIVERSITY OF LIVERPOOL (GB) 2015-12-15 US disclosed
US-20150080592-A1 CATALYST COMPOUNDS THE UNIVERSITY OF LIVERPOOL (GB) 2015-03-19 US disclosed
US-20150073165-A1 CATALYST COMPOUNDS THE UNIVIERSITY OF LIVERPOOL (GB) 2015-03-12 US disclosed
EP-2836496-A1 CATALYST COMPOUNDS The University of Liverpool (GB) 2015-02-18 EP disclosed
EP-2836497-A1 CATALYST COMPOUNDS The University of Liverpool (GB) 2015-02-18 EP disclosed
WO-2013153407-A1 CATALYST COMPOUNDS THE UNIVERSITY OF LIVERPOOL (GB) 2013-10-17 WO disclosed
WO-2013153408-A1 CATALYST COMPOUNDS THE UNIVERSITY OF LIVERPOOL (GB) 2013-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12491503-B2 Hydrogenation process of oxime derivatives HMOX2, HAO2, PRDX5 NOS3 342/4885HTR3E 1615/4885HTR3B 2847/4885
US-20150073165-A1 CATALYST COMPOUNDS NQO1, IDH2, IDH3B NOS3 979/4885HTR3E 3781/4885HTR3B 2288/4885
US-20210387173-A1 HYDROGENATION PROCESS OF OXIME DERIVATIVES HMOX2, HAO2, PRDX5 NOS3 342/4885HTR3E 1615/4885HTR3B 2847/4885
US-20150080592-A1 CATALYST COMPOUNDS IDH3B, IDH2, NQO1 NOS3 1370/4885HTR3E 3874/4885HTR3B 2403/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.