Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532744 | 0.80 | L3MBTL1 (0.39) | RAB9AL3MBTL1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL627191 | 0.67 | RAB9A (0.35) | RAB9AL3MBTL1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL9423732 | 0.66 | MEN1 (0.43) | RAB9AKDM4EALDH1A1LMNAHTT | |
| SCHEMBL7209808 | 0.66 | CA2 (0.46) | RAB9AL3MBTL1PDE4APDE4BPDE4C | |
| SCHEMBL7197852 | 0.64 | SIRT2 (0.49) | RAB9APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7295427 | 0.63 | PLAT (0.32) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7296783 | 0.62 | DDB1 (0.37) | HTR1ASLC6A2SLC6A4SLC6A3PDE4A | |
| SCHEMBL7293888 | 0.60 | CA12 (0.35) | RAB9AL3MBTL1SLC6A2SLC6A4PDE4A | |
| SCHEMBL7303598 | 0.60 | CA12 (0.35) | RAB9AHTR1APDE4APDE4BPDE4C | |
| SCHEMBL6819349 | 0.59 | SLC6A2 (0.42) | SLC6A2SLC6A4PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345920-B1 | NOVEL SULFAMIDES AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-04-12 | — | — | EP | disclosed |