SCHEMBL15329906

SCHEMBL15329906

CCOc1ccc(CC(=O)O)c(F)c1[Si](C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.40
RXRB P28702 1/20 0.40
RXRG P48443 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
GLA P06280 1/20 0.40
TSHR P16473 1/20 0.39
HSD17B10 Q99714 3/20 0.37
CXCL8 P10145 1/20 0.36
MAPK1 P28482 2/20 0.35
ALDH1A1 P00352 3/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 2/20 0.35
RAB9A P51151 2/20 0.35
RXFP1 Q9HBX9 1/20 0.35
PTGER4 P35408 1/20 0.35
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
GAA P10253 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9899219 0.85 GLA (0.46) RXRARXRBRXRGL3MBTL1GLA
SCHEMBL9979371 0.79 RXRA (0.42) RXRARXRBRXRGL3MBTL1GLA
SCHEMBL15330024 0.78 CTSL (0.33) L3MBTL1TSHRHSD17B10MAPK1ALDH1A1
SCHEMBL15339930 0.78 MAPK1 (0.43) L3MBTL1TSHRMAPK1KDM4ERAB9A
SCHEMBL15339929 0.76 ALDH1A1 (0.32) TSHRMAPK1ALDH1A1MEN1KMT2A
SCHEMBL2139124 0.73 HSD17B10 (0.56) TSHRHSD17B10CXCL8MAPK1ALDH1A1
SCHEMBL15339931 0.73 KDM4E (0.42) TSHRMAPK1ALDH1A1KDM4EGAA
SCHEMBL29532573 0.73 HSD17B10 (0.56) TSHRHSD17B10CXCL8MAPK1ALDH1A1
SCHEMBL23229170 0.73 HSD17B10 (0.51) RXRARXRBRXRGL3MBTL1GLA
SCHEMBL15329852 0.72 LMNA (0.41) L3MBTL1ALDH1A1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9102871-B2 Liquid crystal compound showing negative dielectric anisotropy, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-08-11 US disclosed
US-9102871-B2 Liquid crystal compound showing negative dielectric anisotropy, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-08-11 US disclosed
US-20130277610-A1 LIQUID CRYSTAL COMPOUND SHOWING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-24 US disclosed
US-20130277610-A1 LIQUID CRYSTAL COMPOUND SHOWING NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-10-24 US disclosed