SCHEMBL15330784

SCHEMBL15330784

OB(O)c1ccc(-c2ncon2)c(C(F)(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.35
ENPP2 Q13822 1/20 0.35
CASP6 P55212 1/20 0.32
CNR2 P34972 1/20 0.32
GLA P06280 1/20 0.31
POLB P06746 1/20 0.31
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
SCD O00767 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2550962 0.81 ENPP2 (0.38) ENPP2CASP6
SCHEMBL15330562 0.78 ENPP2 (0.38) ENPP2CASP6
SCHEMBL15330585 0.77 ENPP2 (0.35) ENPP2CASP6
SCHEMBL15331346 0.77 ABL1 (0.37) ENPP2CASP6CNR2
SCHEMBL28847412 0.73 NOTUM (0.47) TSHRSCD
SCHEMBL15330290 0.71 S1PR1 (0.36) CNR2SCD
SCHEMBL15329827 0.71 MGLL (0.35) MGLLCASP6CNR2
SCHEMBL28412610 0.70 ALOX5AP (0.42) CASP6CNR2POLB
SCHEMBL15330020 0.70 CA2 (0.42) MGLLENPP2TSHR
SCHEMBL15330988 0.70 MGLL (0.39) MGLLCNR2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed