SCHEMBL15330290

SCHEMBL15330290

OB(O)c1ccc(-c2ncon2)cc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 6/20 0.36
GPR119 Q8TDV5 1/20 0.35
NOTUM Q6P988 4/20 0.34
ERN1 O75460 1/20 0.33
KMO O15229 1/20 0.33
SCD O00767 1/20 0.32
KAT6A Q92794 1/20 0.32
CNR1 P21554 1/20 0.32
KCNH2 Q12809 1/20 0.32
CNR2 P34972 1/20 0.32
CASP3 P42574 1/20 0.32
PSEN1 P49768 1/20 0.32
PSEN2 P49810 1/20 0.32
APH1B Q8WW43 1/20 0.32
NCSTN Q92542 1/20 0.32
APH1A Q96BI3 1/20 0.32
PSENEN Q9NZ42 1/20 0.32
S1PR3 Q99500 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15330200 0.81 KAT6A (0.39) GPR119KMOKAT6APSEN1PSEN2
SCHEMBL15332626 0.78 KAT6A (0.39) GPR119KMOKAT6APSEN1PSEN2
SCHEMBL23864913 0.77 S1PR1 (0.50) S1PR1
SCHEMBL15331513 0.76 KMO (0.36) S1PR1GPR119KMOKAT6AS1PR3
SCHEMBL15329827 0.74 MGLL (0.35) NOTUMCNR1KCNH2CNR2
SCHEMBL2550405 0.74 RXRA (0.48) S1PR1KCNH2S1PR3
SCHEMBL11714109 0.73 RAB9A (0.39) NOTUMKAT6A
SCHEMBL30118405 0.73 IDO1 (0.40) S1PR1SCD
SCHEMBL15330784 0.71 MGLL (0.35) SCDCNR2
SCHEMBL493936 0.70 KIF11 (0.45) S1PR1NOTUMCNR1KCNH2CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed