SCHEMBL15329827

SCHEMBL15329827

OB(O)c1ccc(C(F)(F)F)cc1-c1ncon1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.35
CNR1 P21554 1/20 0.34
KCNH2 Q12809 1/20 0.34
LIPE Q05469 6/20 0.32
NOTUM Q6P988 1/20 0.32
HCRTR1 O43613 1/20 0.32
HCRTR2 O43614 1/20 0.32
CYP3A4 P08684 1/20 0.32
ORAI1 Q96D31 1/20 0.32
ORAI2 Q96SN7 1/20 0.32
ORAI3 Q9BRQ5 1/20 0.32
TRPV6 Q9H1D0 1/20 0.32
CASP6 P55212 1/20 0.32
CNR2 P34972 1/20 0.32
NR1I2 O75469 1/20 0.31
BRS3 P32247 1/20 0.31
PPARG P37231 1/20 0.31
PPARD Q03181 1/20 0.31
PPARA Q07869 1/20 0.31
EPHX2 P34913 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15331474 0.81 CASP6 (0.43) HCRTR1HCRTR2CYP3A4CASP6
SCHEMBL28412610 0.79 ALOX5AP (0.42) CNR1KCNH2CASP6CNR2EPHX2
SCHEMBL15330290 0.74 S1PR1 (0.36) CNR1KCNH2NOTUMCNR2
SCHEMBL21352408 0.73 CASP6 (0.36) LIPECASP6PPARA
SCHEMBL15329720 0.72 CASP6 (0.43) HCRTR1HCRTR2CYP3A4CASP6
SCHEMBL15330784 0.71 MGLL (0.35) MGLLCASP6CNR2
SCHEMBL15010815 0.70 KIF11 (0.52) MGLLORAI1ORAI2ORAI3TRPV6
SCHEMBL493936 0.70 KIF11 (0.45) CNR1KCNH2NOTUM
SCHEMBL15330988 0.70 MGLL (0.39) MGLLCNR1KCNH2CNR2
SCHEMBL4831479 0.69 PTGDR2 (0.49) MGLLTRPV6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed