Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.57 |
| ▸ | PIM1 | P11309 | 6/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CLK2 | P49760 | 4/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.53 |
| ▸ | CDC7 | O00311 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 3/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.53 |
| ▸ | GSK3A | P49840 | 3/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15340899 | 0.81 | TRPA1 (0.52) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL15345023 | 0.79 | TRPA1 (0.48) | GSK3BROCK2PIM1AURKBDYRK1A | |
| SCHEMBL3799521 | 0.78 | CLK1 (0.61) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL30805622 | 0.78 | GSK3B (0.63) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL27989422 | 0.78 | ROCK2 (0.52) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL15344998 | 0.78 | TRPA1 (0.48) | GSK3BROCK2PIM1DYRK1ACDK2 | |
| SCHEMBL26619294 | 0.77 | KMO (0.55) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL16573980 | 0.77 | GSK3B (0.71) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL13680578 | 0.76 | GSK3B (0.70) | GSK3BROCK2PIM1AURKBJAK2 | |
| SCHEMBL29409358 | 0.76 | ROCK2 (0.59) | GSK3BROCK2PIM1AURKBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070081-B1 | BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION | GILEAD SCIENCES INC (US) | 2018-02-28 | — | — | EP | disclosed |
| US-20160152582-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-06-02 | — | — | US | disclosed |
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-01-21 | — | — | US | disclosed |
| US-9096586-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-8987250-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130281434-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281434-A1 | THERAPEUTIC COMPOUNDS | NFATC1, FURIN, CD4 | GSK3B 3128/4885ROCK2 1658/4885PIM1 1422/4885 |
| US-20160015690-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | GSK3B 1719/4885ROCK2 1591/4885PIM1 1335/4885 |
| US-20130281433-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | GSK3B 1719/4885ROCK2 1591/4885PIM1 1335/4885 |
| US-20160152582-A1 | THERAPEUTIC COMPOUNDS | NFATC1, FURIN, CD4 | GSK3B 3128/4885ROCK2 1658/4885PIM1 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.